An immunotoxin composed of an antibody to the human transferrin receptor (454A12) and ricin A chain (RTA) was shown to inhibit the growth of NIH:OVCAR-3 tumors in a nude mouse model of human ovarian cancer. Inhibition of tumor growth by 454A12-RTA was related to the dose administered. The antitumor activity of the immunotoxin was blocked by coinjection of excess antibody with immunotoxin. An immunotoxin made using 454Al2 and recombinant ricin A chain (rRTA) had an activity similar to that made with native RTA. The administration of 10 μg or greater of the immunotoxin 454A12-RTA/rRTA had significant antitumor activity. The injection of 30 μg of an irrelevant immunotoxin, MOPC21-RTA, or 30 to 500 μg of the 454A12 antibody had no antitumor activity.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Mar 1987|
ASJC Scopus subject areas
- Cancer Research