Antitumour immune responses

Roshni Mitra, Sarvjeet Singh, Ashok Khar

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The role of the immune system in combating tumour progression has been studied extensively. The two branches of the immune response-humoral and cell-mediated-act both independently and in concert to combat tumour progression, the success of which depends on the immunogenicity of the tumour cells. The immune system discriminates between transformed cells and normal cells by virtue of the presence of unique antigens on tumour cells. Despite this, the immune system is not always able to detect and kill cancerous cells because neoplasms have also evolved various strategies to escape immune surveillance. Attempts are being made to trigger the immune system into an early and efficient response against malignant cells, and various therapeutic modalities are being developed to enhance the strength of the immune response against tumours. This review aims to elucidate the tumouricidal role of various components of the immune system, including macrophages, lymphocytes, dendritic cells and complement.

Original languageEnglish (US)
JournalExpert Reviews in Molecular Medicine
Volume5
Issue number3
DOIs
StatePublished - Jan 13 2003

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Immune System
Neoplasms
Neoplasm Antigens
Humoral Immunity
Dendritic Cells
Macrophages
Lymphocytes
Therapeutics

Keywords

  • cellular immunity
  • cytokines
  • humoral immunity
  • tumor
  • tumor antigen
  • tumor cell death
  • tumour
  • tumour antigen
  • tumour cell death
  • Tumour immunity

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Antitumour immune responses. / Mitra, Roshni; Singh, Sarvjeet; Khar, Ashok.

In: Expert Reviews in Molecular Medicine, Vol. 5, No. 3, 13.01.2003.

Research output: Contribution to journalReview article

Mitra, Roshni ; Singh, Sarvjeet ; Khar, Ashok. / Antitumour immune responses. In: Expert Reviews in Molecular Medicine. 2003 ; Vol. 5, No. 3.
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