TY - JOUR
T1 - Anxiety and cognition in female histidine decarboxylase knockout (Hdc -/-) mice
AU - Acevedo, Summer F.
AU - Pfankuch, Timothy
AU - Ohtsu, Hiroshi
AU - Raber, Jacob
N1 - Funding Information:
This work was supported by NIH Grants R01 AG20904 and EMF AG-NS-0201-02.
PY - 2006/3/15
Y1 - 2006/3/15
N2 - The role of histamine in brain function has been studied using histidine decarboxylase (HDC) deficient male mice. As the effects of HDC deficiency on brain function might be sex-dependent, we behaviorally analyzed Hdc -/- and control female mice. Compared to female control mice, Hdc-/- female mice showed hypoactivity, increased measures of anxiety, impairments in water-maze performance, but enhanced passive avoidance memory retention. Following behavioral testing, arginine vasopression (AVP) immunoreactivity was higher in the dorsal hypothalamus and central and basolateral nuclei of the amygdala of Hdc-/- than Hdc+/+ mice. Finally, MAP2 immunoreactivity in the hippocampal CA1 region correlated positively with measures of anxiety in the open-field and light-dark tests and negatively with performance during the hidden sessions of the water-maze. As the effects of HDC deficiency on object recognition, water-maze, and rotorod performance, were sex-dependent, it is important to consider potential effects of sex in the interpretation of the role of histaminergic neurotransmission in brain function.
AB - The role of histamine in brain function has been studied using histidine decarboxylase (HDC) deficient male mice. As the effects of HDC deficiency on brain function might be sex-dependent, we behaviorally analyzed Hdc -/- and control female mice. Compared to female control mice, Hdc-/- female mice showed hypoactivity, increased measures of anxiety, impairments in water-maze performance, but enhanced passive avoidance memory retention. Following behavioral testing, arginine vasopression (AVP) immunoreactivity was higher in the dorsal hypothalamus and central and basolateral nuclei of the amygdala of Hdc-/- than Hdc+/+ mice. Finally, MAP2 immunoreactivity in the hippocampal CA1 region correlated positively with measures of anxiety in the open-field and light-dark tests and negatively with performance during the hidden sessions of the water-maze. As the effects of HDC deficiency on object recognition, water-maze, and rotorod performance, were sex-dependent, it is important to consider potential effects of sex in the interpretation of the role of histaminergic neurotransmission in brain function.
KW - Elevated plus-maze
KW - Elevated zero-maze
KW - Light-dark
KW - Microtubule-associated protein 2
KW - Open-field
KW - Water-maze
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U2 - 10.1016/j.bbr.2005.10.016
DO - 10.1016/j.bbr.2005.10.016
M3 - Article
C2 - 16310870
AN - SCOPUS:31544458713
SN - 0166-4328
VL - 168
SP - 92
EP - 99
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -