AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway

Désirée Fehr, Carlo Casanova, Amy Liverman, Hana Blazkova, Kim Orth, Dirk Dobbelaere, Joachim Frey, Sarah E. Burr

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Aeromonas salmonicida subsp. salmonicida contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The aopP gene was detected in both typical and atypical A. salmonicida isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-κB) signalling pathways. AopP inhibits the NF-κB pathway downstream of IκB kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway.

Original languageEnglish (US)
Pages (from-to)2809-2818
Number of pages10
JournalMicrobiology
Volume152
Issue number9
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Microbiology

Fingerprint Dive into the research topics of 'AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway'. Together they form a unique fingerprint.

  • Cite this

    Fehr, D., Casanova, C., Liverman, A., Blazkova, H., Orth, K., Dobbelaere, D., Frey, J., & Burr, S. E. (2006). AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway. Microbiology, 152(9), 2809-2818. https://doi.org/10.1099/mic.0.28889-0