TY - JOUR
T1 - Aortic dissection in young adults who abuse amphetamines
AU - Westover, Arthur N.
AU - Nakonezny, Paul A.
N1 - Funding Information:
This study was supported by National Institutes of Health funding (CTSA grant UL1 RR024982 ). The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the paper, and its final contents.
PY - 2010/8
Y1 - 2010/8
N2 - Background: Case reports suggest a relationship between amphetamine abuse/dependence and aortic dissection, but no population-based epidemiologic studies have examined this link. Our objective was to test the hypothesis that young adults with a diagnosis of amphetamine abuse/dependence would be at higher risk for aortic dissection after accounting for known risk factors. Methods: In this population-based case-control study of 30,922,098 discharges from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1995 to 2007, among persons aged 18 to 49 years, we identified 3,116 thoracic and thoracoabdominal aortic dissections using International Classification of Disease, Ninth Edition, Clinical Modification codes 441.01 and 441.03. The SURVEYLOGISTIC procedure in SAS 9.2 (SAS Institute, Cary, NC) was used to account for the Nationwide Inpatient Sample sampling methodology. Results: In a multiple logistic regression analysis, while controlling for known risk factors, amphetamine abuse/dependence was significantly associated with aortic dissection (adjusted odds ratio = 3.33, 95% CI = 2.37-4.69, P < .0001). Conclusions: This statistically significant association suggests that amphetamine abuse/dependence may play a role in aortic dissection in young adults in the United States.
AB - Background: Case reports suggest a relationship between amphetamine abuse/dependence and aortic dissection, but no population-based epidemiologic studies have examined this link. Our objective was to test the hypothesis that young adults with a diagnosis of amphetamine abuse/dependence would be at higher risk for aortic dissection after accounting for known risk factors. Methods: In this population-based case-control study of 30,922,098 discharges from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1995 to 2007, among persons aged 18 to 49 years, we identified 3,116 thoracic and thoracoabdominal aortic dissections using International Classification of Disease, Ninth Edition, Clinical Modification codes 441.01 and 441.03. The SURVEYLOGISTIC procedure in SAS 9.2 (SAS Institute, Cary, NC) was used to account for the Nationwide Inpatient Sample sampling methodology. Results: In a multiple logistic regression analysis, while controlling for known risk factors, amphetamine abuse/dependence was significantly associated with aortic dissection (adjusted odds ratio = 3.33, 95% CI = 2.37-4.69, P < .0001). Conclusions: This statistically significant association suggests that amphetamine abuse/dependence may play a role in aortic dissection in young adults in the United States.
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U2 - 10.1016/j.ahj.2010.05.021
DO - 10.1016/j.ahj.2010.05.021
M3 - Article
C2 - 20691838
AN - SCOPUS:77955442826
SN - 0002-8703
VL - 160
SP - 315
EP - 321
JO - American heart journal
JF - American heart journal
IS - 2
ER -