Apamin improves reference memory but not procedural memory in rats by blocking small conductance Ca2+-activated K+ channels in an olfactory discrimination task

C. Fournier, S. Kourrich, B. Soumireu-Mourat, C. Mourre

Research output: Contribution to journalArticle

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Abstract

Apamin blocks SK channels responsible for long-lasting hyperpolarization following the action potential. Using an olfactory associative task, the effect of an intracerebroventricular 0.3 ng apamin injection was tested on learning and memory. Apamin did not modify the learning of the procedure side of the task or the learning of the odor-reward association. To test reference memory specifically, the rats were trained on a new odor-association problem using the same procedure (acquisition session), and they were tested for retention 24 h later. Apamin injected before or after the acquisition session improved retention of the valence of a new odor pair. Apamin injected before the retention session did not affect the retrieval of the new valence. Thus, the results indicate that the blockage of apamin-sensitive SK channels facilitate consolidation on new-odor-reward association.

Original languageEnglish (US)
Pages (from-to)81-93
Number of pages13
JournalBehavioural Brain Research
Volume121
Issue number1-2
DOIs
StatePublished - Mar 28 2001

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Keywords

  • Afterhyperpolarization
  • Behavior
  • Calcium-activated potassium channel
  • Hippocampus
  • Learning
  • Memory
  • Odor-reward association
  • Potassium channels

ASJC Scopus subject areas

  • Behavioral Neuroscience

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