Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma

Hong Peng, Qiuyang Zhang, Jiali Li, Ning Zhang, Yunpeng Hua, Lixia Xu, Yubin Deng, Jiaming Lai, Zhenwei Peng, Baogang Peng, Minhu Chen, Sui Peng, Ming Kuang

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Tumor cells co-express vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) that interact each other to support a self-sustainable cell growth. So far, this autocrine VEGF loop is not reported in human intrahepatic cholangiocarcinoma (ICC). Apatinib is a highly selective VEGFR2 inhibitor, but its effects on ICC have not been investigated. In this study, we reported that VEGF and phosphorylated VEGFR2 were expressed at a significantly high level in ICC patient tissues (P

Original languageEnglish (US)
Pages (from-to)17220-17229
Number of pages10
JournalOncotarget
Volume7
Issue number13
DOIs
StatePublished - Mar 29 2016

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Cholangiocarcinoma
Vascular Endothelial Growth Factor A
Apoptosis
Vascular Endothelial Growth Factor Receptor
Growth
apatinib
Neoplasms

Keywords

  • Apatinib
  • Apoptosis
  • Intrahepatic cholangiocarcinoma
  • PI3K
  • VEGFR2

ASJC Scopus subject areas

  • Oncology

Cite this

Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma. / Peng, Hong; Zhang, Qiuyang; Li, Jiali; Zhang, Ning; Hua, Yunpeng; Xu, Lixia; Deng, Yubin; Lai, Jiaming; Peng, Zhenwei; Peng, Baogang; Chen, Minhu; Peng, Sui; Kuang, Ming.

In: Oncotarget, Vol. 7, No. 13, 29.03.2016, p. 17220-17229.

Research output: Contribution to journalArticle

Peng, H, Zhang, Q, Li, J, Zhang, N, Hua, Y, Xu, L, Deng, Y, Lai, J, Peng, Z, Peng, B, Chen, M, Peng, S & Kuang, M 2016, 'Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma', Oncotarget, vol. 7, no. 13, pp. 17220-17229. https://doi.org/10.18632/oncotarget.7948
Peng, Hong ; Zhang, Qiuyang ; Li, Jiali ; Zhang, Ning ; Hua, Yunpeng ; Xu, Lixia ; Deng, Yubin ; Lai, Jiaming ; Peng, Zhenwei ; Peng, Baogang ; Chen, Minhu ; Peng, Sui ; Kuang, Ming. / Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma. In: Oncotarget. 2016 ; Vol. 7, No. 13. pp. 17220-17229.
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