Apelin has in vivo inotropic effects on normal and failing hearts

Mark F. Berry, Timothy J. Pirolli, Vasant Jayasankar, Jeffrey Burdick, Kevin J. Morine, Timothy J. Gardner, Y. Joseph Woo

Research output: Contribution to journalArticle

213 Scopus citations

Abstract

Background-Apelin has been shown ex vivo to be a potent cardiac inotrope. This study was undertaken to evaluate the in vivo effects of apelin on cardiac function in native and ischemic cardiomyopathic rat hearts using a novel combination of a perivascular flow probe and a conductance catheter. Methods and Results-Native rats (n = 32) and rats in heart failure 6 weeks after left anterior descending coronary artery ligation (n = 22) underwent median sternotomy with placement of a perivascular flow probe around the ascending aorta and a pressure volume conductance catheter into the left ventricle. Compared with sham-operated rats, the ligated rats had significantly decreased baseline Pmax and max dP/dt. Continuous infusion of apelin at a rate of 0.01 μg/min for 20 minutes significantly increased Pmax and max dP/dt compared with infusion of vehicle alone in both native and failing hearts. Apelin infusion increased cardiac contractility, indicated by a significant increase in stroke volume (SV) without a change in left ventricular end diastolic volume (102±16% change from initial SV versus 26±20% for native animals, and 110±30% versus 26±11% for ligated animals), as well as an increase in preload recruitable stroke work (180±24 mm Hg versus 107±9 mm Hg for native animals). Conclusions-The present study is the first to show that apelin has positive inotropic effects in vivo in both normal rat hearts and rat hearts in failure after myocardial infarction. Apelin may have use as an acute inotropic agent in patients with ischemic heart failure.

Original languageEnglish (US)
Pages (from-to)II187-II193
JournalCirculation
Volume110
Issue number11 SUPPL.
DOIs
StatePublished - Sep 14 2004

Keywords

  • Apelin
  • Cardiac output
  • Heart failure
  • Hemodynamics
  • Inotropic agents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Berry, M. F., Pirolli, T. J., Jayasankar, V., Burdick, J., Morine, K. J., Gardner, T. J., & Woo, Y. J. (2004). Apelin has in vivo inotropic effects on normal and failing hearts. Circulation, 110(11 SUPPL.), II187-II193. https://doi.org/10.1161/01.CIR.0000138382.57325.5c