Apheresis days required for harvesting CD34 cells predicts hematopoietic recovery and survival following autologous transplantation

S. Malik, B. Bolwell, L. Rybicki, O. Copelan, H. Duong, R. Dean, R. Sobecks, M. Kalaycio, J. Sweetenham, B. Pohlman, S. Andresen, S. Tench, A. Koo, P. Figueroa, E. Copelan

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9 Scopus citations

Abstract

We sought to determine whether patients requiring more aphereses to obtain adequate numbers of CD34 cells had delayed hematopoietic recovery following autologous transplantation. We identified 496 consecutive individuals with lymphoma who underwent hematopoietic stem cell mobilization using etoposide and G-CSF and first autologous transplantation. In multivariate analysis, increased apheresis days as a continuous and as a categorical variable at 5/5 days significantly predicted neutrophil recovery. Apheresis days fell just short of significance (P0.06) as a predictor of platelet recovery in multivariate analysis. Increased apheresis days (as both continuous and categorical variables) were also predictive of treatment-related myelodysplastic syndrome/AML. Patients who underwent 5 days of pheresis had significantly worse survival (P0.001) than patients with less pheresis days owing to significantly higher relapse mortality (P0.001).

Original languageEnglish (US)
Pages (from-to)1519-1525
Number of pages7
JournalBone Marrow Transplantation
Volume46
Issue number12
DOIs
StatePublished - Dec 1 2011

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Keywords

  • CD34+ cells
  • apheresis days
  • autologous transplantation
  • hematopoietic recovery

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Malik, S., Bolwell, B., Rybicki, L., Copelan, O., Duong, H., Dean, R., Sobecks, R., Kalaycio, M., Sweetenham, J., Pohlman, B., Andresen, S., Tench, S., Koo, A., Figueroa, P., & Copelan, E. (2011). Apheresis days required for harvesting CD34 cells predicts hematopoietic recovery and survival following autologous transplantation. Bone Marrow Transplantation, 46(12), 1519-1525. https://doi.org/10.1038/bmt.2010.336