Apicomplexan infections in the gut

C. L. Wilhelm, Felix Yarovinsky

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Toxoplasma gondii and Cryptosporidium parvum are intracellular protozoan parasites that establish infection through the small intestinal bowel after the ingestion of contaminated food products. These Apicomplexan parasites have emerged as an important cause of chronic and fatal disease in immunodeficient individuals, in addition to being investigated as possible triggers of inflammatory bowel disease. T. gondii disseminates to the brain and other tissues after infection, whereas C. parvum remains localized to the intestine. In the following review, we will discuss the pathogenesis of these parasitic diseases in the small intestine, the site of initial invasion. Themes include the sequence of invasion, the structure of Th1 immunity provoked by these parasites and the contribution of intestinal microbiota to the development of the mucosal immune response.

Original languageEnglish (US)
Pages (from-to)409-420
Number of pages12
JournalParasite Immunology
Volume36
Issue number9
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cryptosporidium parvum
  • IFNg
  • Microbiota
  • Parasite
  • Th1
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Parasitology
  • Immunology

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    Wilhelm, C. L., & Yarovinsky, F. (2014). Apicomplexan infections in the gut. Parasite Immunology, 36(9), 409-420. https://doi.org/10.1111/pim.12115