APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell count

Soo Jin Cho, Henning Drechsler, Ryan C. Burke, Max Q. Arens, William Powderly, Nicholas O. Davidson

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

APOBEC3F and APOBEC3G (hA3F and hA3G) are part of an innate mechanism of antiretroviral defense. The human immunodeficiency virus type 1 (HIV-1) accessory protein Vif targets both proteins for proteasomal degradation. Using mRNA from peripheral blood mononuclear cells of 92 HIV-infected subjects not taking antiretroviral therapy and 19 HIV-uninfected controls, we found that hA3F (P < 0.001) and hA3G (P = 0.016) mRNA levels were lower in HIV-infected subjects and were positively correlated with one another (P = 0.003). However, we found no correlation in the abundance of either hA3F or hA3G mRNA with either viral load or CD4 counts in HIV-infected subjects.

Original languageEnglish (US)
Pages (from-to)2069-2072
Number of pages4
JournalJournal of Virology
Volume80
Issue number4
DOIs
StatePublished - Feb 2006

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Viremia
viremia
CD4 Lymphocyte Count
mononuclear leukocytes
viral load
protein degradation
Human immunodeficiency virus 1
HIV-1
T-lymphocytes
HIV
T-Lymphocytes
therapeutics
Messenger RNA
vif Gene Products
proteins
Viral Load
Proteolysis
Blood Cells
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell count. / Cho, Soo Jin; Drechsler, Henning; Burke, Ryan C.; Arens, Max Q.; Powderly, William; Davidson, Nicholas O.

In: Journal of Virology, Vol. 80, No. 4, 02.2006, p. 2069-2072.

Research output: Contribution to journalArticle

Cho, Soo Jin ; Drechsler, Henning ; Burke, Ryan C. ; Arens, Max Q. ; Powderly, William ; Davidson, Nicholas O. / APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell count. In: Journal of Virology. 2006 ; Vol. 80, No. 4. pp. 2069-2072.
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