TY - JOUR
T1 - APOE genotype modifies the association between central arterial stiffening and cognition in older adults
AU - Cambronero, Francis E.
AU - Liu, Dandan
AU - Neal, Jacquelyn E.
AU - Moore, Elizabeth E.
AU - Gifford, Katherine A.
AU - Terry, James G.
AU - Nair, Sangeeta
AU - Pechman, Kimberly R.
AU - Osborn, Katie E.
AU - Hohman, Timothy J.
AU - Bell, Susan P.
AU - Sweatt, J. David
AU - Wang, Thomas J.
AU - Beckman, Joshua A.
AU - Carr, John Jeffrey
AU - Jefferson, Angela L.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/7
Y1 - 2018/7
N2 - Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment (n = 121, 73 ± 8 years, 42% APOE-ε4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s). Linear regression models stratified by cognitive diagnosis related aortic PWV × APOE-ε4 status to neuropsychological performances, adjusting for demographic and vascular risk factors. PWV × APOE-ε4 related to poorer performance on measures of lexical retrieval (β = −0.29, p = 0.01), executive function (β = −0.44, p = 0.02), and episodic memory (β = −3.07, p = 0.02). Among participants with higher aortic PWV, APOE-ε4 modified the association between central arterial stiffening and cognition, such that carriers had worse performances than noncarriers. Findings add to a growing body of evidence for APOE-vascular interactions on cognition in older adults and warrant further research into less heart-healthy cohorts where the association between PWV and cognition among older adults might be stronger.
AB - Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment (n = 121, 73 ± 8 years, 42% APOE-ε4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s). Linear regression models stratified by cognitive diagnosis related aortic PWV × APOE-ε4 status to neuropsychological performances, adjusting for demographic and vascular risk factors. PWV × APOE-ε4 related to poorer performance on measures of lexical retrieval (β = −0.29, p = 0.01), executive function (β = −0.44, p = 0.02), and episodic memory (β = −3.07, p = 0.02). Among participants with higher aortic PWV, APOE-ε4 modified the association between central arterial stiffening and cognition, such that carriers had worse performances than noncarriers. Findings add to a growing body of evidence for APOE-vascular interactions on cognition in older adults and warrant further research into less heart-healthy cohorts where the association between PWV and cognition among older adults might be stronger.
KW - Aging
KW - Alzheimer's disease
KW - Cardiac MRI
KW - Mild cognitive impairment
KW - Pulse wave velocity
KW - Vascular risk factors
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U2 - 10.1016/j.neurobiolaging.2018.02.009
DO - 10.1016/j.neurobiolaging.2018.02.009
M3 - Article
C2 - 29656011
AN - SCOPUS:85045274751
SN - 0197-4580
VL - 67
SP - 120
EP - 127
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -