APOE genotypes associate with cognitive performance but not cerebral structure: Diabetes heart study MIND

Nicholette D. Allred, Laura M. Raffield, Joycelyn C. Hardy, Fang Chi Hsu, Jasmin Divers, Jianzhao Xu, S. Carrie Smith, Christina E. Hugenschmidt, Benjamin C. Wagner, Christopher T. Whitlow, Kaycee M. Sink, Joseph A Maldjian, Jeff D. Williamson, Donald W. Bowden, Barry I. Freedman

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE Dementia is a debilitating illness with a disproportionate burden in patients with type 2 diabetes (T2D). Among the contributors, genetic variation at the apolipoprotein E locus (APOE) is posited to convey a strong effect. This study compared and contrasted the association of APOE with cognitive performance and cerebral structure in the setting of T2D. RESEARCH DESIGN AND METHODS European Americans from the Diabetes Heart Study (DHS) MIND (n = 754) and African Americans from the African American (AA)-DHS MIND (n = 517) were examined. The cognitive battery assessed executive function, memory, and global cognition, and brain MRI was performed. RESULTS In European Americans and African Americans, the APOE E4 risk haplotype group was associated with poorer performance on the modified Mini-Mental Status Examination (P < 0.017), a measure of global cognition. In contrast to the literature, the APOE E2 haplotype group, which was overrepresented in these participants with T2D, was associated with poorer Rey Auditory Verbal Learning Test performance (P < 0.032). Nominal associations between APOE haplotype groups and MRI-determined cerebral structure were observed. CONCLUSIONS Compared with APOE E3 carriers, E2 and E4 carriers performed worse in the cognitive domains of memory and global cognition. Identification of genetic contributors remains critical to understanding new pathways to prevent and treat dementia in the setting of T2D.

Original languageEnglish (US)
Pages (from-to)2225-2231
Number of pages7
JournalDiabetes Care
Volume39
Issue number12
DOIs
StatePublished - Jan 1 2016

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Apolipoproteins E
Genotype
Type 2 Diabetes Mellitus
African Americans
Cognition
Haplotypes
Dementia
Verbal Learning
Executive Function
Research Design
Brain

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Allred, N. D., Raffield, L. M., Hardy, J. C., Hsu, F. C., Divers, J., Xu, J., ... Freedman, B. I. (2016). APOE genotypes associate with cognitive performance but not cerebral structure: Diabetes heart study MIND. Diabetes Care, 39(12), 2225-2231. https://doi.org/10.2337/dc16-0843

APOE genotypes associate with cognitive performance but not cerebral structure : Diabetes heart study MIND. / Allred, Nicholette D.; Raffield, Laura M.; Hardy, Joycelyn C.; Hsu, Fang Chi; Divers, Jasmin; Xu, Jianzhao; Smith, S. Carrie; Hugenschmidt, Christina E.; Wagner, Benjamin C.; Whitlow, Christopher T.; Sink, Kaycee M.; Maldjian, Joseph A; Williamson, Jeff D.; Bowden, Donald W.; Freedman, Barry I.

In: Diabetes Care, Vol. 39, No. 12, 01.01.2016, p. 2225-2231.

Research output: Contribution to journalArticle

Allred, ND, Raffield, LM, Hardy, JC, Hsu, FC, Divers, J, Xu, J, Smith, SC, Hugenschmidt, CE, Wagner, BC, Whitlow, CT, Sink, KM, Maldjian, JA, Williamson, JD, Bowden, DW & Freedman, BI 2016, 'APOE genotypes associate with cognitive performance but not cerebral structure: Diabetes heart study MIND', Diabetes Care, vol. 39, no. 12, pp. 2225-2231. https://doi.org/10.2337/dc16-0843
Allred, Nicholette D. ; Raffield, Laura M. ; Hardy, Joycelyn C. ; Hsu, Fang Chi ; Divers, Jasmin ; Xu, Jianzhao ; Smith, S. Carrie ; Hugenschmidt, Christina E. ; Wagner, Benjamin C. ; Whitlow, Christopher T. ; Sink, Kaycee M. ; Maldjian, Joseph A ; Williamson, Jeff D. ; Bowden, Donald W. ; Freedman, Barry I. / APOE genotypes associate with cognitive performance but not cerebral structure : Diabetes heart study MIND. In: Diabetes Care. 2016 ; Vol. 39, No. 12. pp. 2225-2231.
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T1 - APOE genotypes associate with cognitive performance but not cerebral structure

T2 - Diabetes heart study MIND

AU - Allred, Nicholette D.

AU - Raffield, Laura M.

AU - Hardy, Joycelyn C.

AU - Hsu, Fang Chi

AU - Divers, Jasmin

AU - Xu, Jianzhao

AU - Smith, S. Carrie

AU - Hugenschmidt, Christina E.

AU - Wagner, Benjamin C.

AU - Whitlow, Christopher T.

AU - Sink, Kaycee M.

AU - Maldjian, Joseph A

AU - Williamson, Jeff D.

AU - Bowden, Donald W.

AU - Freedman, Barry I.

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N2 - OBJECTIVE Dementia is a debilitating illness with a disproportionate burden in patients with type 2 diabetes (T2D). Among the contributors, genetic variation at the apolipoprotein E locus (APOE) is posited to convey a strong effect. This study compared and contrasted the association of APOE with cognitive performance and cerebral structure in the setting of T2D. RESEARCH DESIGN AND METHODS European Americans from the Diabetes Heart Study (DHS) MIND (n = 754) and African Americans from the African American (AA)-DHS MIND (n = 517) were examined. The cognitive battery assessed executive function, memory, and global cognition, and brain MRI was performed. RESULTS In European Americans and African Americans, the APOE E4 risk haplotype group was associated with poorer performance on the modified Mini-Mental Status Examination (P < 0.017), a measure of global cognition. In contrast to the literature, the APOE E2 haplotype group, which was overrepresented in these participants with T2D, was associated with poorer Rey Auditory Verbal Learning Test performance (P < 0.032). Nominal associations between APOE haplotype groups and MRI-determined cerebral structure were observed. CONCLUSIONS Compared with APOE E3 carriers, E2 and E4 carriers performed worse in the cognitive domains of memory and global cognition. Identification of genetic contributors remains critical to understanding new pathways to prevent and treat dementia in the setting of T2D.

AB - OBJECTIVE Dementia is a debilitating illness with a disproportionate burden in patients with type 2 diabetes (T2D). Among the contributors, genetic variation at the apolipoprotein E locus (APOE) is posited to convey a strong effect. This study compared and contrasted the association of APOE with cognitive performance and cerebral structure in the setting of T2D. RESEARCH DESIGN AND METHODS European Americans from the Diabetes Heart Study (DHS) MIND (n = 754) and African Americans from the African American (AA)-DHS MIND (n = 517) were examined. The cognitive battery assessed executive function, memory, and global cognition, and brain MRI was performed. RESULTS In European Americans and African Americans, the APOE E4 risk haplotype group was associated with poorer performance on the modified Mini-Mental Status Examination (P < 0.017), a measure of global cognition. In contrast to the literature, the APOE E2 haplotype group, which was overrepresented in these participants with T2D, was associated with poorer Rey Auditory Verbal Learning Test performance (P < 0.032). Nominal associations between APOE haplotype groups and MRI-determined cerebral structure were observed. CONCLUSIONS Compared with APOE E3 carriers, E2 and E4 carriers performed worse in the cognitive domains of memory and global cognition. Identification of genetic contributors remains critical to understanding new pathways to prevent and treat dementia in the setting of T2D.

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