Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms

A useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans

Mikhail Lisovsky, Mai P. Hoang, Karen A. Dresser, Payal Kapur, Jag Bhawan, Meera Mahalingam

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

More recent techniques to characterize the genetic profile of soft-tissue tumors include the use of gene arrays. Using this technique, Apolipoprotein D (Apo D), a 33-kDa glycoprotein component of high-density lipoprotein, has been found to be highly expressed in dermatofibrosarcoma protuberans. To corroborate these results, we sought to ascertain the utility of Apo D by investigating its sensitivity and specificity in a variety of CD34-positive and CD34-negative cutaneous neoplasms including superficial acral fibromyxoma, sclerotic fibromas, and cellular dermatofibromas. Of interest, we found absence of Apo D expression in all four cases of superficial acral fibromyxoma. Of the remaining CD34-positive lesions, Apo D expression was noted in 35/36 (97%) cases of dermatofibrosarcoma protuberans, 3/5 (60%) giant-cell fibroblastomas, 4/4 (100%) sclerotic fibromas, 8/8 (100%) neurofibromas, and 1/1 (100%) solitary fibrous tumor. Of the CD34-negative lesions, Apo D expression was noted in 2/22 (9%) regular dermatofibroma, 23/45 (51%) cellular dermatofibroma, 10/10 (100%) malignant fibrous histiocytoma, 9/10 (90%) atypical fibroxanthoma, 7/8 (86%) cellular neurothekeoma, 9/9 (100%) malignant melanoma, 8/8 (100%) melanocytic nevi (100%), 0/2 superficial angiomyxoma, 0/15 fibromatosis, 0/1 nodular fasciitis, and 1/2 (50%) desmoplastic fibroblastomas. In summary, our findings indicate that Apo D expression is not specific to dermatofibrosarcoma protuberans. Its principal use as an immunohistochemical adjunct lies in its utility in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. Although strong positive staining of Apo D in a markedly atypical fibrohistiocytic lesion is suggestive of atypical fibroxanthoma and/or malignant fibrous histiocytoma, further studies with the inclusion of other atypical spindled cell neoplasms are required to conclusively prove the same.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalModern Pathology
Volume21
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Apolipoproteins D
Dermatofibrosarcoma
Fibroma
Skin Neoplasms
Extremities
Benign Fibrous Histiocytoma
Malignant Fibrous Histiocytoma
Neurothekeoma
Solitary Fibrous Tumors
Fasciitis
Pigmented Nevus
Neurofibroma
Myxoma
HDL Lipoproteins
Melanoma
Neoplasms
Glycoproteins
Staining and Labeling
Sensitivity and Specificity

Keywords

  • Apo D
  • Apolipoprotein D
  • CD34
  • Dermatofibrosarcoma protuberans
  • Superficial acral fibromyxoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms : A useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. / Lisovsky, Mikhail; Hoang, Mai P.; Dresser, Karen A.; Kapur, Payal; Bhawan, Jag; Mahalingam, Meera.

In: Modern Pathology, Vol. 21, No. 1, 01.2008, p. 31-38.

Research output: Contribution to journalArticle

@article{eab732a9e41248b9a2396e5550d66337,
title = "Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: A useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans",
abstract = "More recent techniques to characterize the genetic profile of soft-tissue tumors include the use of gene arrays. Using this technique, Apolipoprotein D (Apo D), a 33-kDa glycoprotein component of high-density lipoprotein, has been found to be highly expressed in dermatofibrosarcoma protuberans. To corroborate these results, we sought to ascertain the utility of Apo D by investigating its sensitivity and specificity in a variety of CD34-positive and CD34-negative cutaneous neoplasms including superficial acral fibromyxoma, sclerotic fibromas, and cellular dermatofibromas. Of interest, we found absence of Apo D expression in all four cases of superficial acral fibromyxoma. Of the remaining CD34-positive lesions, Apo D expression was noted in 35/36 (97{\%}) cases of dermatofibrosarcoma protuberans, 3/5 (60{\%}) giant-cell fibroblastomas, 4/4 (100{\%}) sclerotic fibromas, 8/8 (100{\%}) neurofibromas, and 1/1 (100{\%}) solitary fibrous tumor. Of the CD34-negative lesions, Apo D expression was noted in 2/22 (9{\%}) regular dermatofibroma, 23/45 (51{\%}) cellular dermatofibroma, 10/10 (100{\%}) malignant fibrous histiocytoma, 9/10 (90{\%}) atypical fibroxanthoma, 7/8 (86{\%}) cellular neurothekeoma, 9/9 (100{\%}) malignant melanoma, 8/8 (100{\%}) melanocytic nevi (100{\%}), 0/2 superficial angiomyxoma, 0/15 fibromatosis, 0/1 nodular fasciitis, and 1/2 (50{\%}) desmoplastic fibroblastomas. In summary, our findings indicate that Apo D expression is not specific to dermatofibrosarcoma protuberans. Its principal use as an immunohistochemical adjunct lies in its utility in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. Although strong positive staining of Apo D in a markedly atypical fibrohistiocytic lesion is suggestive of atypical fibroxanthoma and/or malignant fibrous histiocytoma, further studies with the inclusion of other atypical spindled cell neoplasms are required to conclusively prove the same.",
keywords = "Apo D, Apolipoprotein D, CD34, Dermatofibrosarcoma protuberans, Superficial acral fibromyxoma",
author = "Mikhail Lisovsky and Hoang, {Mai P.} and Dresser, {Karen A.} and Payal Kapur and Jag Bhawan and Meera Mahalingam",
year = "2008",
month = "1",
doi = "10.1038/modpathol.3800971",
language = "English (US)",
volume = "21",
pages = "31--38",
journal = "Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms

T2 - A useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans

AU - Lisovsky, Mikhail

AU - Hoang, Mai P.

AU - Dresser, Karen A.

AU - Kapur, Payal

AU - Bhawan, Jag

AU - Mahalingam, Meera

PY - 2008/1

Y1 - 2008/1

N2 - More recent techniques to characterize the genetic profile of soft-tissue tumors include the use of gene arrays. Using this technique, Apolipoprotein D (Apo D), a 33-kDa glycoprotein component of high-density lipoprotein, has been found to be highly expressed in dermatofibrosarcoma protuberans. To corroborate these results, we sought to ascertain the utility of Apo D by investigating its sensitivity and specificity in a variety of CD34-positive and CD34-negative cutaneous neoplasms including superficial acral fibromyxoma, sclerotic fibromas, and cellular dermatofibromas. Of interest, we found absence of Apo D expression in all four cases of superficial acral fibromyxoma. Of the remaining CD34-positive lesions, Apo D expression was noted in 35/36 (97%) cases of dermatofibrosarcoma protuberans, 3/5 (60%) giant-cell fibroblastomas, 4/4 (100%) sclerotic fibromas, 8/8 (100%) neurofibromas, and 1/1 (100%) solitary fibrous tumor. Of the CD34-negative lesions, Apo D expression was noted in 2/22 (9%) regular dermatofibroma, 23/45 (51%) cellular dermatofibroma, 10/10 (100%) malignant fibrous histiocytoma, 9/10 (90%) atypical fibroxanthoma, 7/8 (86%) cellular neurothekeoma, 9/9 (100%) malignant melanoma, 8/8 (100%) melanocytic nevi (100%), 0/2 superficial angiomyxoma, 0/15 fibromatosis, 0/1 nodular fasciitis, and 1/2 (50%) desmoplastic fibroblastomas. In summary, our findings indicate that Apo D expression is not specific to dermatofibrosarcoma protuberans. Its principal use as an immunohistochemical adjunct lies in its utility in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. Although strong positive staining of Apo D in a markedly atypical fibrohistiocytic lesion is suggestive of atypical fibroxanthoma and/or malignant fibrous histiocytoma, further studies with the inclusion of other atypical spindled cell neoplasms are required to conclusively prove the same.

AB - More recent techniques to characterize the genetic profile of soft-tissue tumors include the use of gene arrays. Using this technique, Apolipoprotein D (Apo D), a 33-kDa glycoprotein component of high-density lipoprotein, has been found to be highly expressed in dermatofibrosarcoma protuberans. To corroborate these results, we sought to ascertain the utility of Apo D by investigating its sensitivity and specificity in a variety of CD34-positive and CD34-negative cutaneous neoplasms including superficial acral fibromyxoma, sclerotic fibromas, and cellular dermatofibromas. Of interest, we found absence of Apo D expression in all four cases of superficial acral fibromyxoma. Of the remaining CD34-positive lesions, Apo D expression was noted in 35/36 (97%) cases of dermatofibrosarcoma protuberans, 3/5 (60%) giant-cell fibroblastomas, 4/4 (100%) sclerotic fibromas, 8/8 (100%) neurofibromas, and 1/1 (100%) solitary fibrous tumor. Of the CD34-negative lesions, Apo D expression was noted in 2/22 (9%) regular dermatofibroma, 23/45 (51%) cellular dermatofibroma, 10/10 (100%) malignant fibrous histiocytoma, 9/10 (90%) atypical fibroxanthoma, 7/8 (86%) cellular neurothekeoma, 9/9 (100%) malignant melanoma, 8/8 (100%) melanocytic nevi (100%), 0/2 superficial angiomyxoma, 0/15 fibromatosis, 0/1 nodular fasciitis, and 1/2 (50%) desmoplastic fibroblastomas. In summary, our findings indicate that Apo D expression is not specific to dermatofibrosarcoma protuberans. Its principal use as an immunohistochemical adjunct lies in its utility in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. Although strong positive staining of Apo D in a markedly atypical fibrohistiocytic lesion is suggestive of atypical fibroxanthoma and/or malignant fibrous histiocytoma, further studies with the inclusion of other atypical spindled cell neoplasms are required to conclusively prove the same.

KW - Apo D

KW - Apolipoprotein D

KW - CD34

KW - Dermatofibrosarcoma protuberans

KW - Superficial acral fibromyxoma

UR - http://www.scopus.com/inward/record.url?scp=37549002941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37549002941&partnerID=8YFLogxK

U2 - 10.1038/modpathol.3800971

DO - 10.1038/modpathol.3800971

M3 - Article

VL - 21

SP - 31

EP - 38

JO - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

SN - 0893-3952

IS - 1

ER -