It is now well established that members of the low-density lipoprotein (LDL) receptor gene family are crucial regulators of different aspects of neuronal development, synaptic plasticity, maintenance of neuronal homeostasis, and neurodegeneration. This was highlighted in particular by the discovery that the lipoprotein receptors apolipoprotein E receptor-2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR) function as receptors for the neuronal signaling protein Reelin. In this chapter, we will briefly introduce the family of LDL receptor-related proteins and review the functions of its members ApoER2 and VLDLR as Reelin receptors and their role in the developing and adult brain.
|Original language||English (US)|
|Title of host publication||Reelin Glycoprotein|
|Subtitle of host publication||Structure, Biology and Roles in Health and Disease|
|Publisher||Springer New York|
|Number of pages||21|
|State||Published - Jan 1 2008|
ASJC Scopus subject areas