Apolipoprotein E receptors

Linking brain development and Alzheimer's disease

Joachim Herz, Uwe Beffert

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Alzheimer's disease is a debilitating neurodegenerative disorder that afflicts an increasing part of our ageing population. An isoform of apolipoprotein E, a protein that mediates the transport of lipids and cholesterol in the circulatory system, predisposes carriers of this allele to the common late-onset form of the disease. How this protein is related to a neurodegenerative disorder is an enigma. Mounting evidence indicates that apolipoprotein E receptors, which are abundantly expressed in most neurons in the central nervous system, also fulfil critical functions during brain development and may profoundly influence the pathogenesis of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalNature Reviews Neuroscience
Volume1
Issue number1
StatePublished - Oct 2000

Fingerprint

Low Density Lipoprotein Receptor-Related Protein-1
Brain Diseases
Neurodegenerative Diseases
Alzheimer Disease
Apolipoproteins E
Protein Transport
Cardiovascular System
Protein Isoforms
Central Nervous System
Alleles
Cholesterol
Lipids
Neurons
Brain
Population
Proteins
Late Onset Disorders

ASJC Scopus subject areas

  • Cell Biology
  • Neuroscience(all)

Cite this

Apolipoprotein E receptors : Linking brain development and Alzheimer's disease. / Herz, Joachim; Beffert, Uwe.

In: Nature Reviews Neuroscience, Vol. 1, No. 1, 10.2000, p. 51-58.

Research output: Contribution to journalArticle

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