Apolipoproteins in human cerebrospinal fluid

P. S. Roheim, M. Carey, T. Forte, G. L. Vega

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Abstract

The presence of apolipoproteins A-I, E, C-II, and C-III and the absence of apolipoprotein B was demonstrated in human cerebrospinal fluid. The concentration of apolipoproteins was measured by electroimmunoassay. Apolipoprotein E, C-II, and C-III were present in cerebrospinal fluid at 3-5% of their concentration in plasma; the cerebrospinal fluid level of apolipoprotein A-I was 0,4%. Most of the cerebrospinal fluid apolipoproteins were present in the p<1.21 g/ml lipoprotein fraction. The major apolipoproteins of cerebrospinal fluid are E and A-I. The possible mechanism of transfer and the physiological and pathophysiological role of apolipoproteins in cerebrospinal fluid are postulated.

Original languageEnglish (US)
Pages (from-to)4646-4649
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number9
DOIs
StatePublished - Jan 1 1979

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