Apoptosis and lung cancer: A review

Narayan Shivapurkar, Jyotsna Reddy, Preet M. Chaudhary, Adi F. Gazdar

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

It is important to understand the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death. Defects in apoptosis are implicated in both tumorigenesis and drug resistance, and these defects are cause of chemotherapy failures. These studies should explain the relationship between cancer genetics and treatment sensitivity, and should enable a more rational approach to anticancer drug design and therapy. Lung cancer is a major cause of cancer deaths throughout the world. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) represent the two major categories of lung cancer that differ in their sensitivity to undergo apoptosis. The role of apoptosis regulation in lung cancer with major focus on the differential sensitivities of the major subtypes is reviewed.

Original languageEnglish (US)
Pages (from-to)885-898
Number of pages14
JournalJournal of Cellular Biochemistry
Volume88
Issue number5
DOIs
StatePublished - Apr 1 2003

Fingerprint

Lung Neoplasms
Apoptosis
Cells
Pharmaceutical Preparations
Drug Therapy
Neoplasms
Defects
Chemotherapy
Drug Design
Small Cell Lung Carcinoma
Drug Resistance
Non-Small Cell Lung Carcinoma
Tumors
Cause of Death
Carcinogenesis
Therapeutics

Keywords

  • Apoptosis
  • Chemosensitivity
  • Lung cancer
  • P53

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Shivapurkar, N., Reddy, J., Chaudhary, P. M., & Gazdar, A. F. (2003). Apoptosis and lung cancer: A review. Journal of Cellular Biochemistry, 88(5), 885-898. https://doi.org/10.1002/jcb.10440

Apoptosis and lung cancer : A review. / Shivapurkar, Narayan; Reddy, Jyotsna; Chaudhary, Preet M.; Gazdar, Adi F.

In: Journal of Cellular Biochemistry, Vol. 88, No. 5, 01.04.2003, p. 885-898.

Research output: Contribution to journalArticle

Shivapurkar, N, Reddy, J, Chaudhary, PM & Gazdar, AF 2003, 'Apoptosis and lung cancer: A review', Journal of Cellular Biochemistry, vol. 88, no. 5, pp. 885-898. https://doi.org/10.1002/jcb.10440
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF. Apoptosis and lung cancer: A review. Journal of Cellular Biochemistry. 2003 Apr 1;88(5):885-898. https://doi.org/10.1002/jcb.10440
Shivapurkar, Narayan ; Reddy, Jyotsna ; Chaudhary, Preet M. ; Gazdar, Adi F. / Apoptosis and lung cancer : A review. In: Journal of Cellular Biochemistry. 2003 ; Vol. 88, No. 5. pp. 885-898.
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