Apoptosis and lung cancer: A review

Narayan Shivapurkar, Jyotsna Reddy, Preet M. Chaudhary, Adi F. Gazdar

Research output: Contribution to journalReview article

164 Scopus citations

Abstract

It is important to understand the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death. Defects in apoptosis are implicated in both tumorigenesis and drug resistance, and these defects are cause of chemotherapy failures. These studies should explain the relationship between cancer genetics and treatment sensitivity, and should enable a more rational approach to anticancer drug design and therapy. Lung cancer is a major cause of cancer deaths throughout the world. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) represent the two major categories of lung cancer that differ in their sensitivity to undergo apoptosis. The role of apoptosis regulation in lung cancer with major focus on the differential sensitivities of the major subtypes is reviewed.

Original languageEnglish (US)
Pages (from-to)885-898
Number of pages14
JournalJournal of Cellular Biochemistry
Volume88
Issue number5
DOIs
StatePublished - Apr 1 2003

Keywords

  • Apoptosis
  • Chemosensitivity
  • Lung cancer
  • P53

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Shivapurkar, N., Reddy, J., Chaudhary, P. M., & Gazdar, A. F. (2003). Apoptosis and lung cancer: A review. Journal of Cellular Biochemistry, 88(5), 885-898. https://doi.org/10.1002/jcb.10440