Apoptosis in neural development and disease

Deepak Nijhawan, Narimon Honarpour, Xiaodong Wang

Research output: Contribution to journalReview article

241 Scopus citations

Abstract

Cell death via apoptosis is a prominent feature in mammalian neural development. Recent studies into the basic mechanism of apoptosis have revealed biochemical pathways that control and execute apoptosis in mammalian cells. Protein factors in these pathways play important roles during development in regulating the balance between neuronal life and death. Additionally, mounting evidence indicates such pathways may also be activated during several neurodegenerative diseases, resulting in improper loss of neurons.

Original languageEnglish (US)
Pages (from-to)73-87
Number of pages15
JournalAnnual Review of Neuroscience
Volume23
DOIs
StatePublished - Jun 24 2000

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Keywords

  • Apaf-1
  • Bcl-2
  • Caspase
  • Cytochrome c
  • Neurodegenerative

ASJC Scopus subject areas

  • Neuroscience(all)

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