Abstract
Dioscin, a saponin extracted from the root of Polygonatum Zanlanscianense Pamp, markedly inhibited proliferation of Hela cells. The results indicated that Hela cells underwent apoptosis in dose- and time-dependent manners when treated with Dioscin. Caspase-3, -8 and -9 activities were also detected. The low enzymatic activity of caspase-8 and high activity of caspase-9 showed that the mitochondrial pathway was activated in apoptosis. The reduced expression of the survival protein Bcl-2 also confirmed this result. These studies may be significant in finding a new drug to treat human cervical cancer.
Original language | English (US) |
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Pages (from-to) | 193-196 |
Number of pages | 4 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 25 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2002 |
Externally published | Yes |
Keywords
- Apoptosis
- Bcl-2
- Caspase
- Dioscin
- Hela
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science