Abstract
One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.
Original language | English (US) |
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Pages (from-to) | 1851-1854 |
Number of pages | 4 |
Journal | Oncogene |
Volume | 30 |
Issue number | 16 |
DOIs | |
State | Published - Apr 21 2011 |
Externally published | Yes |
Keywords
- CD95
- DAMP
- PUMA
- apoptosis
- autophagy
- tumorigenesis
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research