Apoptosis promotes early tumorigenesis

D. Tang, M. T. Lotze, R. Kang, H. J. Zeh

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.

Original languageEnglish (US)
Pages (from-to)1851-1854
Number of pages4
JournalOncogene
Volume30
Issue number16
DOIs
Publication statusPublished - Apr 21 2011
Externally publishedYes

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Keywords

  • apoptosis
  • autophagy
  • CD95
  • DAMP
  • PUMA
  • tumorigenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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