Apoptotic activity of REAPER is distinct from signaling by the tumor necrosis factor receptor 1 death domain

Po Chen, Pauline Lee, Lisa Otto, John Abrams

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

REAPER (RPR) is a 65-amino acid protein that is critical activator of programmed cell death in Drosophila. On the basis of sequence alignment data, it was recently proposed that RPR might represent an ancestral molecule from which the death domain in a number of proteins may have evolved. We tested this idea by examining the activity of mutations in RPR that parallel inactivation mutations of the tumor necrosis factor receptor 1 death domain. The RPR mutants retained potent apoptotic function, suggesting that cell death activity mediated by RPR is distinct from signaling by the tumor necrosis factor receptor 1 death domain.

Original languageEnglish (US)
Pages (from-to)25735-25737
Number of pages3
JournalJournal of Biological Chemistry
Volume271
Issue number42
DOIs
StatePublished - Oct 29 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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