Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers

Lisa A. Simms, Tong Tong Zou, Joanne Young, Ying Qiang Shi, Junyi Lei, Rebecca Appel, Mun Gan Rhyu, Haruhiko Sugimura, Georgia Chenevix-Trench, Rhonda F. Souza, Stephen J. Meltzer, Barbara A. Leggett

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Genomic instability at simple repeated sequences has been observed in various types of human cancers and is considered an important mechanism in tumorigenesis. Alterations at microsatellite loci have been reported scattered throughout the genome. Recently, the transforming growth factor-β receptor type II (TGF-β RII) and the insulin-like growth factor II receptor (IGF-IIR) genes were shown to have inactivating mutations within coding microsatellite sequences. The demonstration of mutations in two growth regulatory genes supports the idea that other regulatory genes with repeat sequences may also be targets in tumours with defective mismatch repair. We examined genes involved in tumour suppression, cell adhesion and cell cycle regulation for mutations at small repeat sequences in replication error positive gastrointestinal cancers. Several polymorphisms were found which exhibited instability, but no other instability was present in the regions examined.

Original languageEnglish (US)
Pages (from-to)2613-2618
Number of pages6
JournalOncogene
Volume14
Issue number21
DOIs
StatePublished - 1997

Keywords

  • Colorectal cancer
  • Gastric cancer
  • Microsatellite instability
  • Repeats

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Simms, L. A., Zou, T. T., Young, J., Shi, Y. Q., Lei, J., Appel, R., Rhyu, M. G., Sugimura, H., Chenevix-Trench, G., Souza, R. F., Meltzer, S. J., & Leggett, B. A. (1997). Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers. Oncogene, 14(21), 2613-2618. https://doi.org/10.1038/sj.onc.1201094