Apparent unilateral visual neglect in MPTP-hemiparkinsonian monkeys is due to delayed initiation of motion

K. S. Bankiewicz, E. H. Oldfield, R. J. Plunkett, W. H. Schuette, D. G. Cogan, N. Hogan, A. Zuddas, I. J. Kopin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Monkeys made hemiparkinsonian by infusion of a solution of MPTP into one carotid artery appeared to ignore food presented from the contralateral side. Initial observations suggested neglect of visual stimuli presented as fruit treats by automated delivery system in the half-field contralateral to MPTP treatment. Further studies in which fruit treats were left in the 'neglected' visual field indicated that this apparent neglect, unlike neglect attending cortical lesions, was rather a marked delay in initiating movements (unilateral hypokinesia). These observations may explain apparent subcortical neglect and are consistent with the known role of nigrostriatal dopaminergic neurones in movement regulation. This is a useful animal model in which difficulties in initiation of movement (hypokinesia), a cardinal sympton of Parkinson's disease, can be studied separately from other deficits in motor performance.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalBrain Research
Volume541
Issue number1
DOIs
StatePublished - Feb 8 1991

Fingerprint

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Hypokinesia
Haplorhini
Fruit
Dopaminergic Neurons
Visual Fields
Carotid Arteries
Parkinson Disease
Animal Models
Food

Keywords

  • Hypokinesia
  • Monkey
  • MPTP
  • Neglect
  • Parkinson's disease

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Bankiewicz, K. S., Oldfield, E. H., Plunkett, R. J., Schuette, W. H., Cogan, D. G., Hogan, N., ... Kopin, I. J. (1991). Apparent unilateral visual neglect in MPTP-hemiparkinsonian monkeys is due to delayed initiation of motion. Brain Research, 541(1), 98-102. https://doi.org/10.1016/0006-8993(91)91080-K

Apparent unilateral visual neglect in MPTP-hemiparkinsonian monkeys is due to delayed initiation of motion. / Bankiewicz, K. S.; Oldfield, E. H.; Plunkett, R. J.; Schuette, W. H.; Cogan, D. G.; Hogan, N.; Zuddas, A.; Kopin, I. J.

In: Brain Research, Vol. 541, No. 1, 08.02.1991, p. 98-102.

Research output: Contribution to journalArticle

Bankiewicz, KS, Oldfield, EH, Plunkett, RJ, Schuette, WH, Cogan, DG, Hogan, N, Zuddas, A & Kopin, IJ 1991, 'Apparent unilateral visual neglect in MPTP-hemiparkinsonian monkeys is due to delayed initiation of motion', Brain Research, vol. 541, no. 1, pp. 98-102. https://doi.org/10.1016/0006-8993(91)91080-K
Bankiewicz, K. S. ; Oldfield, E. H. ; Plunkett, R. J. ; Schuette, W. H. ; Cogan, D. G. ; Hogan, N. ; Zuddas, A. ; Kopin, I. J. / Apparent unilateral visual neglect in MPTP-hemiparkinsonian monkeys is due to delayed initiation of motion. In: Brain Research. 1991 ; Vol. 541, No. 1. pp. 98-102.
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