Application of cell lineage reprogramming for central nervous system injury and repair

Xiu Sun, Yi Min Yuan, Xin Hu, Shang Yao Qin, Zhi Da Su

Research output: Contribution to journalArticle

Abstract

Transplantation of neural stem cells (NSCs) has become an important therapeutic strategy for central nervous system (CNS) injury; however, the potential immune rejection and ethical concerns limit the transplantation-based cell therapy in clinic. Alternatively, induced pluripotent stem cells (iPSCs) may overcome these major hurdles and cast new lights on cell therapy. Recent studies have shown that a variety of somatic cells from mouse or human can be reprogrammed into NSCs or neurons, suggesting that reprogramming of cell fate may represent a promising strategy for CNS repair. Here, we reviewed the current knowledge of cell lineage reprogramming, reprogramming-mediated induction of NSCs or neurons and their application in CNS repair.

Original languageEnglish (US)
Pages (from-to)729-737
Number of pages9
JournalAcademic Journal of Second Military Medical University
Volume37
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

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Keywords

  • Cell transplantation
  • Central nervous system
  • Neurodegenerative disease
  • Neurotrauma
  • Reprogramming

ASJC Scopus subject areas

  • Medicine(all)

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