Application of current knowledge to the management of bleeding events during immune tolerance induction

Jorge Di Paola, L. Aledort, H. Britton, M. Carcao, E. Grabowski, J. Hutter, J. Journeycake, C. Kempton, C. Leissinger

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The development of inhibitors to factor VIII is the most serious adverse event associated with the treatment of haemophilia A, predisposing patients to uncontrollable haemorrhage, disability and premature death. Eradication of inhibitors via immune tolerance induction (ITI) is effective in the majority of patients, but may require months to years to achieve success. In the interim, the treatment and prevention of acute bleeding episodes are primary foci of care. Regrettably, there is a paucity of information regarding management of bleeding episodes in inhibitor patients undergoing tolerization. Until specific data from ongoing clinical trials are available to provide more guidance in this patient group, it is reasonable and useful to rely on the broader base of medical literature pertaining to patients not being tolerized to deduce strategies for controlling acute and perioperative bleeding episodes in inhibitor patients during ITI.

Original languageEnglish (US)
Pages (from-to)591-597
Number of pages7
JournalHaemophilia
Volume12
Issue number6
DOIs
StatePublished - Nov 1 2006

Keywords

  • Bypassing agents
  • Haemophilia
  • Immune tolerance induction
  • Inhibitor
  • Prophylaxis

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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    Di Paola, J., Aledort, L., Britton, H., Carcao, M., Grabowski, E., Hutter, J., Journeycake, J., Kempton, C., & Leissinger, C. (2006). Application of current knowledge to the management of bleeding events during immune tolerance induction. Haemophilia, 12(6), 591-597. https://doi.org/10.1111/j.1365-2516.2006.01343.x