Application of genetic algorithm to the QSAR research of pyrrolobenzothiazepinones and pyrrolobenzoxazepinones-novel and specific non-nucleoside HIV-1 reverse transcription inhibitors

Ting Jun Hou, Jun Mei Wang, You Yong Li, Xiao Jie Xu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.

Original languageEnglish (US)
Pages (from-to)651-654
Number of pages4
JournalChinese Chemical Letters
Volume9
Issue number7
StatePublished - Dec 1 1998

Keywords

  • GA(genetic algorithm)
  • HIV
  • QSAR

ASJC Scopus subject areas

  • Chemistry(all)

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