Application of high-performance liquid chromatography for the study of the microheterogeneity changes of mouse α-fetoprotein in fetal development

L. T. Wong, C. Y. Lu, D. O. Tinker, J. C. Hsia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Changes in the microheterogeneity of mouse α-fetoprotein (MAFP) during fetal development were investigated by high-performance liquid chromatography (HPLC). A total of six distinct isoforms (Iso-1, Iso-2, Iso-3, Iso-4, Iso-5, Iso-6) of the heterogeneous MAFP were resolved from mouse amniotic fluid (MAF). Analysis of MAF collected at various times revealed that these isoforms were accumulated at different stages of the fetal development.

Original languageEnglish (US)
Pages (from-to)267-272
Number of pages6
JournalJournal of Biochemical and Biophysical Methods
Volume15
Issue number5
DOIs
StatePublished - Mar 1988

Keywords

  • Anion-exchange column
  • Fetal development
  • High-performance liquid chromatography
  • Isoform
  • Microheterogeneity
  • α-Fetoprotein

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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