Application of intensity-modulated radiation therapy for pediatric malignancies

José A. Peñagarícano, Niko Papanikolaou, Yulong Yan, Vaneerat Ratanatharathorn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Novel radiation therapy delivery techniques have moved very slowly in the field of pediatric oncology. Some collaborative groups allow new radiation therapy delivery techniques in their trials. In many instances, the option of using these techniques is not addressed. These newer techniques of radiation delivery have the potential to reduce the probability of the common late effects of radiation and at the same time, potentially improve upon control and survival. The purpose of this study is to show the feasibility of IMRT in pediatric patients. No treatment results or toxicities will be presented. Five patients with a variety of pediatric malignancies received intensity-modulated radiation therapy (IMRT) at our institution as part of their disease management. A rigid immobilization device was developed for each patient and a computed tomography (CT) simulation was performed in the treatment position. In 3 of the patients, magnetic resonance imaging (MRI) scans were coregistered with the planning CT to facilitate target and critical structure delineation. In all but 1 patient, coplanar beam arrangements were used in the IMRT planning process. All IMRT plans exhibited a high degree of conformality. Dose homogeneity inside the tumor and rapid dose falloff outside the target volume is characteristic of IMRT plans, which allows for improved normal tissue sparing. Dose distributions were obtained for all plans, as well as dose and volume relationship histograms, to evaluate the fitness of the plans. IMRT is a viable alternative to conventional treatment techniques for pediatric cancer patients. The improved dose distributions coupled with the ease of delivery of the IMRT fields make this technique very attractive, especially in view of the potential to increase local control and possibly improve on survival.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalMedical Dosimetry
Volume29
Issue number4
DOIs
StatePublished - Dec 2004

Fingerprint

radiation therapy
Radiotherapy
Pediatrics
Neoplasms
delivery
dosage
planning
tomography
Tomography
fitness
Survival
delineation
Radiation Effects
radiation
Disease Management
immobilization
histograms
toxicity
Immobilization
homogeneity

Keywords

  • IMRT
  • Pediatric
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Health Professions(all)
  • Radiation

Cite this

Application of intensity-modulated radiation therapy for pediatric malignancies. / Peñagarícano, José A.; Papanikolaou, Niko; Yan, Yulong; Ratanatharathorn, Vaneerat.

In: Medical Dosimetry, Vol. 29, No. 4, 12.2004, p. 247-253.

Research output: Contribution to journalArticle

Peñagarícano, JA, Papanikolaou, N, Yan, Y & Ratanatharathorn, V 2004, 'Application of intensity-modulated radiation therapy for pediatric malignancies', Medical Dosimetry, vol. 29, no. 4, pp. 247-253. https://doi.org/10.1016/j.meddos.2004.04.007
Peñagarícano, José A. ; Papanikolaou, Niko ; Yan, Yulong ; Ratanatharathorn, Vaneerat. / Application of intensity-modulated radiation therapy for pediatric malignancies. In: Medical Dosimetry. 2004 ; Vol. 29, No. 4. pp. 247-253.
@article{85891618c24c469b92a4812ccc05bf44,
title = "Application of intensity-modulated radiation therapy for pediatric malignancies",
abstract = "Novel radiation therapy delivery techniques have moved very slowly in the field of pediatric oncology. Some collaborative groups allow new radiation therapy delivery techniques in their trials. In many instances, the option of using these techniques is not addressed. These newer techniques of radiation delivery have the potential to reduce the probability of the common late effects of radiation and at the same time, potentially improve upon control and survival. The purpose of this study is to show the feasibility of IMRT in pediatric patients. No treatment results or toxicities will be presented. Five patients with a variety of pediatric malignancies received intensity-modulated radiation therapy (IMRT) at our institution as part of their disease management. A rigid immobilization device was developed for each patient and a computed tomography (CT) simulation was performed in the treatment position. In 3 of the patients, magnetic resonance imaging (MRI) scans were coregistered with the planning CT to facilitate target and critical structure delineation. In all but 1 patient, coplanar beam arrangements were used in the IMRT planning process. All IMRT plans exhibited a high degree of conformality. Dose homogeneity inside the tumor and rapid dose falloff outside the target volume is characteristic of IMRT plans, which allows for improved normal tissue sparing. Dose distributions were obtained for all plans, as well as dose and volume relationship histograms, to evaluate the fitness of the plans. IMRT is a viable alternative to conventional treatment techniques for pediatric cancer patients. The improved dose distributions coupled with the ease of delivery of the IMRT fields make this technique very attractive, especially in view of the potential to increase local control and possibly improve on survival.",
keywords = "IMRT, Pediatric, Radiotherapy",
author = "Pe{\~n}agar{\'i}cano, {Jos{\'e} A.} and Niko Papanikolaou and Yulong Yan and Vaneerat Ratanatharathorn",
year = "2004",
month = "12",
doi = "10.1016/j.meddos.2004.04.007",
language = "English (US)",
volume = "29",
pages = "247--253",
journal = "Medical Dosimetry",
issn = "0958-3947",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Application of intensity-modulated radiation therapy for pediatric malignancies

AU - Peñagarícano, José A.

AU - Papanikolaou, Niko

AU - Yan, Yulong

AU - Ratanatharathorn, Vaneerat

PY - 2004/12

Y1 - 2004/12

N2 - Novel radiation therapy delivery techniques have moved very slowly in the field of pediatric oncology. Some collaborative groups allow new radiation therapy delivery techniques in their trials. In many instances, the option of using these techniques is not addressed. These newer techniques of radiation delivery have the potential to reduce the probability of the common late effects of radiation and at the same time, potentially improve upon control and survival. The purpose of this study is to show the feasibility of IMRT in pediatric patients. No treatment results or toxicities will be presented. Five patients with a variety of pediatric malignancies received intensity-modulated radiation therapy (IMRT) at our institution as part of their disease management. A rigid immobilization device was developed for each patient and a computed tomography (CT) simulation was performed in the treatment position. In 3 of the patients, magnetic resonance imaging (MRI) scans were coregistered with the planning CT to facilitate target and critical structure delineation. In all but 1 patient, coplanar beam arrangements were used in the IMRT planning process. All IMRT plans exhibited a high degree of conformality. Dose homogeneity inside the tumor and rapid dose falloff outside the target volume is characteristic of IMRT plans, which allows for improved normal tissue sparing. Dose distributions were obtained for all plans, as well as dose and volume relationship histograms, to evaluate the fitness of the plans. IMRT is a viable alternative to conventional treatment techniques for pediatric cancer patients. The improved dose distributions coupled with the ease of delivery of the IMRT fields make this technique very attractive, especially in view of the potential to increase local control and possibly improve on survival.

AB - Novel radiation therapy delivery techniques have moved very slowly in the field of pediatric oncology. Some collaborative groups allow new radiation therapy delivery techniques in their trials. In many instances, the option of using these techniques is not addressed. These newer techniques of radiation delivery have the potential to reduce the probability of the common late effects of radiation and at the same time, potentially improve upon control and survival. The purpose of this study is to show the feasibility of IMRT in pediatric patients. No treatment results or toxicities will be presented. Five patients with a variety of pediatric malignancies received intensity-modulated radiation therapy (IMRT) at our institution as part of their disease management. A rigid immobilization device was developed for each patient and a computed tomography (CT) simulation was performed in the treatment position. In 3 of the patients, magnetic resonance imaging (MRI) scans were coregistered with the planning CT to facilitate target and critical structure delineation. In all but 1 patient, coplanar beam arrangements were used in the IMRT planning process. All IMRT plans exhibited a high degree of conformality. Dose homogeneity inside the tumor and rapid dose falloff outside the target volume is characteristic of IMRT plans, which allows for improved normal tissue sparing. Dose distributions were obtained for all plans, as well as dose and volume relationship histograms, to evaluate the fitness of the plans. IMRT is a viable alternative to conventional treatment techniques for pediatric cancer patients. The improved dose distributions coupled with the ease of delivery of the IMRT fields make this technique very attractive, especially in view of the potential to increase local control and possibly improve on survival.

KW - IMRT

KW - Pediatric

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=7444228585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7444228585&partnerID=8YFLogxK

U2 - 10.1016/j.meddos.2004.04.007

DO - 10.1016/j.meddos.2004.04.007

M3 - Article

VL - 29

SP - 247

EP - 253

JO - Medical Dosimetry

JF - Medical Dosimetry

SN - 0958-3947

IS - 4

ER -