Application of muscle-derived stem cells in tissue engineering and regenerative medicine

Background: Muscle satellite cells are a main cell source for the repair of muscle tissue injury, and have been paid extensive attention in the study of muscle tissue regeneration. Objective: To summarize the biological properties of muscle-derived stem cells and its application in the field of tissue engineering and regenerative medicine, and to explore the clinical application value and perspective of muscle-derived stem cells. Methods: We retrieved Vip database and PubMed database for articles concerning the application of muscle-derived stem cells published from January 2000 to April 2011. In titles and abstracts, the key words were "muscle-derived stem cells, muscle satellite cells, tissue engineering, regenerative medicine, adult stem cells, MDSCs, MSCs, ASCs". Articles addressing the application of muscle-derived stem cells were included, and those in the same field published recently or in authorized journals were included. 189 literatures were primarily collected, and a total of 25 literatures were included according to the inclusion criteria. Results and Conclusion: Animal experiments and success clinical experiments suggested that in combination of genetic engineering and tissue engineering, tissue engineered tissues and cytological therapy based on muscle-derived stem cells can be used in various skeletal muscle diseases, myocardial diseases, urinary system and nervous system by safe measures. This provides a good healing perspective for clinical physicians and patients, but the study of muscle-derived stem cells still faced many problems.