Abstract
Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.
Original language | English (US) |
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Pages (from-to) | 558-561 |
Number of pages | 4 |
Journal | Current Opinion in Investigational Drugs |
Volume | 2 |
Issue number | 4 |
State | Published - 2001 |
Keywords
- Antisense
- Bridged nucleic acid
- Hybridization
- Locked nucleic acid
- Oligonucleotide
- Peptide nucleic acid
- Telomerase
ASJC Scopus subject areas
- Pharmacology