Application of PNA and LNA oligomers to chemotherapy

A. N. Elayadi, D. R. Corey

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.

Original languageEnglish (US)
Pages (from-to)558-561
Number of pages4
JournalCurrent Opinion in Investigational Drugs
Volume2
Issue number4
StatePublished - May 15 2001

Keywords

  • Antisense
  • Bridged nucleic acid
  • Hybridization
  • Locked nucleic acid
  • Oligonucleotide
  • Peptide nucleic acid
  • Telomerase

ASJC Scopus subject areas

  • Pharmacology

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