Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer

Joseph M. Caster, Andrew Z. Wang

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Chemoradiotherapy (CRT) plays a key role in the curative treatment of many human cancers. The full utility of this paradigm is often restricted by limitations of conventional drug delivery. Nanotherapeutics have demonstrated great potential to overcome many of these issues. The potential benefits of nanotherapeutics in CRT include improved therapeutic efficacy, decreased toxicity, enhanced real-time in vivo tumor imaging, and the translation of novel small molecule drugs or nucleic acid therapies. Additionally, nanomedicines and radiation therapy exert distinct and complementary effects on the tumor microenvironment which can further enhance therapeutic efficacy compared with either modality alone. In this review, we highlight specific clinical and preclinical examples which demonstrate the potential benefits of nanotherapeutics in CRT.

Original languageEnglish (US)
Pages (from-to)791-803
Number of pages13
JournalTherapeutic Delivery
Volume8
Issue number9
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • chemoradiotherapy
  • drug delivery
  • nanoimaging
  • nanomedicine
  • nanoparticle
  • radiation therapy

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer'. Together they form a unique fingerprint.

Cite this