Applying Quantitative Radiographic Image Markers to Predict Clinical Complications After Aneurysmal Subarachnoid Hemorrhage: A Pilot Study

Gopichandh Danala, Masoom Desai, Bappaditya Ray, Morteza Heidari, Sai Kiran R. Maryada, Calin I. Prodan, Bin Zheng

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Accurately predicting clinical outcome of aneurysmal subarachnoid hemorrhage (aSAH) patients is difficult. The purpose of this study was to develop and test a new fully-automated computer-aided detection (CAD) scheme of brain computed tomography (CT) images to predict prognosis of aSAH patients. A retrospective dataset of 59 aSAH patients was assembled. Each patient had 2 sets of CT images acquired at admission and prior-to-discharge. CAD scheme was applied to segment intracranial brain regions into four subregions, namely, cerebrospinal fluid (CSF), white matter (WM), gray matter (GM), and leaked extraparenchymal blood (EPB), respectively. CAD then detects sulci and computes 9 image features related to 5 volumes of the segmented sulci, EPB, CSF, WM, and GM and 4 volumetrical ratios to sulci. Subsequently, applying a leave-one-case-out cross-validation method embedded with a principal component analysis (PCA) algorithm to generate optimal feature vector, 16 support vector machine (SVM) models were built using CT images acquired either at admission or prior-to-discharge to predict each of eight clinically relevant parameters commonly used to assess patients' prognosis. Finally, a receiver operating characteristics (ROC) method was used to evaluate SVM model performance. Areas under ROC curves of 16 SVM models range from 0.62 ± 0.07 to 0.86 ± 0.07. In general, SVM models trained using CT images acquired at admission yielded higher accuracy to predict short-term clinical outcomes, while SVM models trained using CT images acquired prior-to-discharge demonstrated higher accuracy in predicting long-term clinical outcomes. This study demonstrates feasibility to predict prognosis of aSAH patients using new quantitative image markers generated by SVM models.

Original languageEnglish (US)
Pages (from-to)413-425
Number of pages13
JournalAnnals of biomedical engineering
Volume50
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • Aneurysmal subarachnoid hemorrhage (aSAH)
  • Association between image markers and clinical measures
  • Brain CT images
  • Computer-aided detection (CAD)
  • Prediction of aSAH prognosis
  • Quantitative image markers

ASJC Scopus subject areas

  • Biomedical Engineering

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