Approach to the study of the role of sex hormones in autoimmunity

A. D. Steinberg, K. A. Melez, E. S. Raveche, J. P. Reeves, W. A. Boegel, P. A. Smathers, J. D. Taurog, L. Weinlein, M. Duvic

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161 Citations (Scopus)

Abstract

Investigators from this laboratory have been studying sex hormones in normal and autoimmune mice for the past 10 years. We have found that immune responses to DNA are influenced by sex hormones. Androgens reduce and estrogens increase both spontaneous and immunization-induced antibodies to single-stranded DNA in NZB x NZW, NZB x C3H, NZB x CBA, NZB x DBA mice. Treatment of female NZB/W mice with testosterone or 5 α dihydrotestosterone retards the progress of autoimmunity. Castration is not necessary for this effect. In contrast, danazol has no favorable effect on the disease process. Estrogens cause a marked acceleration of autoimmunity and a reduction in thymus weight. During the course of these studies, we found that a number of problems or variables arise in studying sex hormone effects, including: 1) X-linked genes, 2) metabolism of testosterone to estrogens, 3) dose of hormone, 4) age at which administration is initiated, 5) differential effects of sex hormones on different autoantibodies and various immune responses.

Original languageEnglish (US)
Pages (from-to)1170-1176
Number of pages7
JournalArthritis and Rheumatism
Volume22
Issue number11
DOIs
StatePublished - 1979

Fingerprint

Gonadal Steroid Hormones
Autoimmunity
Estrogens
Testosterone
Inbred NZB Mouse
Danazol
X-Linked Genes
Inbred DBA Mouse
Dihydrotestosterone
Single-Stranded DNA
Castration
Autoantibodies
Thymus Gland
Androgens
Immunization
Research Personnel
Hormones
Weights and Measures
Antibodies
DNA

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Steinberg, A. D., Melez, K. A., Raveche, E. S., Reeves, J. P., Boegel, W. A., Smathers, P. A., ... Duvic, M. (1979). Approach to the study of the role of sex hormones in autoimmunity. Arthritis and Rheumatism, 22(11), 1170-1176. https://doi.org/10.1002/art.1780221103

Approach to the study of the role of sex hormones in autoimmunity. / Steinberg, A. D.; Melez, K. A.; Raveche, E. S.; Reeves, J. P.; Boegel, W. A.; Smathers, P. A.; Taurog, J. D.; Weinlein, L.; Duvic, M.

In: Arthritis and Rheumatism, Vol. 22, No. 11, 1979, p. 1170-1176.

Research output: Contribution to journalArticle

Steinberg, AD, Melez, KA, Raveche, ES, Reeves, JP, Boegel, WA, Smathers, PA, Taurog, JD, Weinlein, L & Duvic, M 1979, 'Approach to the study of the role of sex hormones in autoimmunity', Arthritis and Rheumatism, vol. 22, no. 11, pp. 1170-1176. https://doi.org/10.1002/art.1780221103
Steinberg AD, Melez KA, Raveche ES, Reeves JP, Boegel WA, Smathers PA et al. Approach to the study of the role of sex hormones in autoimmunity. Arthritis and Rheumatism. 1979;22(11):1170-1176. https://doi.org/10.1002/art.1780221103
Steinberg, A. D. ; Melez, K. A. ; Raveche, E. S. ; Reeves, J. P. ; Boegel, W. A. ; Smathers, P. A. ; Taurog, J. D. ; Weinlein, L. ; Duvic, M. / Approach to the study of the role of sex hormones in autoimmunity. In: Arthritis and Rheumatism. 1979 ; Vol. 22, No. 11. pp. 1170-1176.
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