Appropriate invasive and conservative strategies for patients with non-ST elevation acute coronary syndromes

Sameer K. Mehta, James A de Lemos

Research output: Contribution to journalArticle

Abstract

Purpose of review: This review focuses on recent developments in three controversial areas of management of acute coronary syndromes. Recent findings: There are potential benefits of an early invasive treatment strategy (routine cardiac catheterization and revascularization when appropriate) in the elderly, who are at high risk for adverse outcomes and treatment-related complications following acute coronary syndromes. There are developments in the role of low-molecular-weight heparin agents in management of acute coronary syndromes in the modern treatment era, in which early coronary revascularization and use of other potent antiplatelet and antithrombin agents are common. Finally, this review looks at emerging data and controversy regarding the effects of intensive lipid-lowering treatment early after acute coronary syndrome. Recent clinical trials have yielded contradictory results. Summary: This paper evaluates recent evidence in acute coronary syndromes regarding early invasive revascularization strategies in high risk elderly patients, and also discusses controversies regarding the role of low molecular weight heparin and intensive statin regimens.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalCurrent Opinion in Cardiology
Volume20
Issue number6
DOIs
StatePublished - Nov 2005

Fingerprint

Acute Coronary Syndrome
Low Molecular Weight Heparin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Antithrombins
Platelet Aggregation Inhibitors
Cardiac Catheterization
Therapeutics
Clinical Trials
Lipids

Keywords

  • Acute coronary syndromes
  • Age
  • Anticoagulation
  • Lipid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Appropriate invasive and conservative strategies for patients with non-ST elevation acute coronary syndromes. / Mehta, Sameer K.; de Lemos, James A.

In: Current Opinion in Cardiology, Vol. 20, No. 6, 11.2005, p. 536-540.

Research output: Contribution to journalArticle

@article{686bc3064f5e46ceb0f39738372133ce,
title = "Appropriate invasive and conservative strategies for patients with non-ST elevation acute coronary syndromes",
abstract = "Purpose of review: This review focuses on recent developments in three controversial areas of management of acute coronary syndromes. Recent findings: There are potential benefits of an early invasive treatment strategy (routine cardiac catheterization and revascularization when appropriate) in the elderly, who are at high risk for adverse outcomes and treatment-related complications following acute coronary syndromes. There are developments in the role of low-molecular-weight heparin agents in management of acute coronary syndromes in the modern treatment era, in which early coronary revascularization and use of other potent antiplatelet and antithrombin agents are common. Finally, this review looks at emerging data and controversy regarding the effects of intensive lipid-lowering treatment early after acute coronary syndrome. Recent clinical trials have yielded contradictory results. Summary: This paper evaluates recent evidence in acute coronary syndromes regarding early invasive revascularization strategies in high risk elderly patients, and also discusses controversies regarding the role of low molecular weight heparin and intensive statin regimens.",
keywords = "Acute coronary syndromes, Age, Anticoagulation, Lipid",
author = "Mehta, {Sameer K.} and {de Lemos}, {James A}",
year = "2005",
month = "11",
doi = "10.1097/01.hco.0000179820.72953.65",
language = "English (US)",
volume = "20",
pages = "536--540",
journal = "Current Opinion in Cardiology",
issn = "0268-4705",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Appropriate invasive and conservative strategies for patients with non-ST elevation acute coronary syndromes

AU - Mehta, Sameer K.

AU - de Lemos, James A

PY - 2005/11

Y1 - 2005/11

N2 - Purpose of review: This review focuses on recent developments in three controversial areas of management of acute coronary syndromes. Recent findings: There are potential benefits of an early invasive treatment strategy (routine cardiac catheterization and revascularization when appropriate) in the elderly, who are at high risk for adverse outcomes and treatment-related complications following acute coronary syndromes. There are developments in the role of low-molecular-weight heparin agents in management of acute coronary syndromes in the modern treatment era, in which early coronary revascularization and use of other potent antiplatelet and antithrombin agents are common. Finally, this review looks at emerging data and controversy regarding the effects of intensive lipid-lowering treatment early after acute coronary syndrome. Recent clinical trials have yielded contradictory results. Summary: This paper evaluates recent evidence in acute coronary syndromes regarding early invasive revascularization strategies in high risk elderly patients, and also discusses controversies regarding the role of low molecular weight heparin and intensive statin regimens.

AB - Purpose of review: This review focuses on recent developments in three controversial areas of management of acute coronary syndromes. Recent findings: There are potential benefits of an early invasive treatment strategy (routine cardiac catheterization and revascularization when appropriate) in the elderly, who are at high risk for adverse outcomes and treatment-related complications following acute coronary syndromes. There are developments in the role of low-molecular-weight heparin agents in management of acute coronary syndromes in the modern treatment era, in which early coronary revascularization and use of other potent antiplatelet and antithrombin agents are common. Finally, this review looks at emerging data and controversy regarding the effects of intensive lipid-lowering treatment early after acute coronary syndrome. Recent clinical trials have yielded contradictory results. Summary: This paper evaluates recent evidence in acute coronary syndromes regarding early invasive revascularization strategies in high risk elderly patients, and also discusses controversies regarding the role of low molecular weight heparin and intensive statin regimens.

KW - Acute coronary syndromes

KW - Age

KW - Anticoagulation

KW - Lipid

UR - http://www.scopus.com/inward/record.url?scp=27644455500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644455500&partnerID=8YFLogxK

U2 - 10.1097/01.hco.0000179820.72953.65

DO - 10.1097/01.hco.0000179820.72953.65

M3 - Article

C2 - 16234627

AN - SCOPUS:27644455500

VL - 20

SP - 536

EP - 540

JO - Current Opinion in Cardiology

JF - Current Opinion in Cardiology

SN - 0268-4705

IS - 6

ER -