Abstract
Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.
Original language | English (US) |
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Pages (from-to) | 6010-6016 |
Number of pages | 7 |
Journal | Advanced Materials |
Volume | 24 |
Issue number | 45 |
DOIs | |
State | Published - Nov 27 2012 |
Keywords
- aptamer
- colloid science
- contrast agents
- imaging
- self-assembly
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering