Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.

J R Falck, V. J. Schueler, H. R. Jacobson, A. K. Siddhanta, B. Pramanik, J. Capdevila

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial capillary gas-liquid chromatography-mass spectral analysis of the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-epoxyeicosatrienoate regioisomers. These results, in conjunction with the documented in vitro biological activities of the arachidonate epoxygenase metabolites, suggest a role for them in renal function.

Original languageEnglish (US)
Pages (from-to)840-846
Number of pages7
JournalJournal of lipid research
Volume28
Issue number7
StatePublished - Jul 1 1987

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

Fingerprint Dive into the research topics of 'Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.'. Together they form a unique fingerprint.

  • Cite this

    Falck, J. R., Schueler, V. J., Jacobson, H. R., Siddhanta, A. K., Pramanik, B., & Capdevila, J. (1987). Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney. Journal of lipid research, 28(7), 840-846.