Arachidonate epoxygenase

identification of epoxyeicosatrienoic acids in rabbit kidney.

J R Falck, V. J. Schueler, H. R. Jacobson, A. K. Siddhanta, B. Pramanik, J. Capdevila

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial capillary gas-liquid chromatography-mass spectral analysis of the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-epoxyeicosatrienoate regioisomers. These results, in conjunction with the documented in vitro biological activities of the arachidonate epoxygenase metabolites, suggest a role for them in renal function.

Original languageEnglish (US)
Pages (from-to)840-846
Number of pages7
JournalJournal of Lipid Research
Volume28
Issue number7
StatePublished - Jul 1987

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Esters
Liquid chromatography
Rabbits
Kidney
Gas chromatography
Gas Chromatography
Acids
Metabolites
Bioactivity
Spectrum analysis
arachidonate epoxygenase
bromohydrins
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology

Cite this

Falck, J. R., Schueler, V. J., Jacobson, H. R., Siddhanta, A. K., Pramanik, B., & Capdevila, J. (1987). Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney. Journal of Lipid Research, 28(7), 840-846.

Arachidonate epoxygenase : identification of epoxyeicosatrienoic acids in rabbit kidney. / Falck, J R; Schueler, V. J.; Jacobson, H. R.; Siddhanta, A. K.; Pramanik, B.; Capdevila, J.

In: Journal of Lipid Research, Vol. 28, No. 7, 07.1987, p. 840-846.

Research output: Contribution to journalArticle

Falck, JR, Schueler, VJ, Jacobson, HR, Siddhanta, AK, Pramanik, B & Capdevila, J 1987, 'Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.', Journal of Lipid Research, vol. 28, no. 7, pp. 840-846.
Falck JR, Schueler VJ, Jacobson HR, Siddhanta AK, Pramanik B, Capdevila J. Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney. Journal of Lipid Research. 1987 Jul;28(7):840-846.
Falck, J R ; Schueler, V. J. ; Jacobson, H. R. ; Siddhanta, A. K. ; Pramanik, B. ; Capdevila, J. / Arachidonate epoxygenase : identification of epoxyeicosatrienoic acids in rabbit kidney. In: Journal of Lipid Research. 1987 ; Vol. 28, No. 7. pp. 840-846.
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