Abstract
Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial capillary gas-liquid chromatography-mass spectral analysis of the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-epoxyeicosatrienoate regioisomers. These results, in conjunction with the documented in vitro biological activities of the arachidonate epoxygenase metabolites, suggest a role for them in renal function.
Original language | English (US) |
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Pages (from-to) | 840-846 |
Number of pages | 7 |
Journal | Journal of lipid research |
Volume | 28 |
Issue number | 7 |
State | Published - Jul 1987 |
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Cell Biology