Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid

Paul Mosset; Pendri Yadagiri; Sun Lumin; Jorge Capdevila; J. R. Falck

doi:10.1016/S0040-4039(00)85391-5

Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid

Paul Mosset, Pendri Yadagiri, Sun Lumin, Jorge Capdevila, J. R. Falck

Biochemistry

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Both enantiomers of the epoxygenase metabolites 8,9- and 11,12-epoxyeicosatrienoic acid (EET) were synthesized by a convergent strategy utilizing dimethyl D- or L-malate and erythrospecific epoxidation.

Original language	English (US)
Pages (from-to)	6035-6038
Number of pages	4
Journal	Tetrahedron Letters
Volume	27
Issue number	50
DOIs	https://doi.org/10.1016/S0040-4039(00)85391-5
State	Published - 1986

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)85391-5

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title = "Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid",

abstract = "Both enantiomers of the epoxygenase metabolites 8,9- and 11,12-epoxyeicosatrienoic acid (EET) were synthesized by a convergent strategy utilizing dimethyl D- or L-malate and erythrospecific epoxidation.",

author = "Paul Mosset and Pendri Yadagiri and Sun Lumin and Jorge Capdevila and Falck, {J. R.}",

year = "1986",

doi = "10.1016/S0040-4039(00)85391-5",

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volume = "27",

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journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Arachidonate epoxygenase

T2 - Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid

AU - Mosset, Paul

AU - Yadagiri, Pendri

AU - Lumin, Sun

AU - Capdevila, Jorge

AU - Falck, J. R.

PY - 1986

Y1 - 1986

N2 - Both enantiomers of the epoxygenase metabolites 8,9- and 11,12-epoxyeicosatrienoic acid (EET) were synthesized by a convergent strategy utilizing dimethyl D- or L-malate and erythrospecific epoxidation.

AB - Both enantiomers of the epoxygenase metabolites 8,9- and 11,12-epoxyeicosatrienoic acid (EET) were synthesized by a convergent strategy utilizing dimethyl D- or L-malate and erythrospecific epoxidation.

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U2 - 10.1016/S0040-4039(00)85391-5

DO - 10.1016/S0040-4039(00)85391-5

M3 - Article

AN - SCOPUS:0012331326

SN - 0040-4039

VL - 27

SP - 6035

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid

Abstract

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