Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine

Robert Toto, Arup Siddhanta, Sukumar Manna, Bikash Pramanik, J. R. Faick, Jorge Capdevila

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Epoxyeicosatrienoic acids, metabolites of the cytochrome P-450-mediated epoxygenase reaction, were detected in human urine by gas chromatographic-mass spectroscopic techniques after conversion to their hydrogenated and non-hydrogenated methyl and pentafluorobenzyl esters. Initial analysis of the regioisomeric composition utilizing the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-isomers.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume919
Issue number2
DOIs
StatePublished - Jun 2 1987

Keywords

  • (Human)
  • Arachidonic acid
  • Epoxygenase
  • Epoxyicosatrienoic acid
  • Urinary metabolite

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

Fingerprint Dive into the research topics of 'Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine'. Together they form a unique fingerprint.

  • Cite this