Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex

Armando Karara, Elizabeth Dishman, Harry Jacobson, J. R. Falck, Jorge H. Capdevila

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Mass spectral and Chromatographic analysis demonstrates the presence of 14,15-, 11,12- and 8,9-epoxyeicosatrienoic acids (44%, 33% and 23% of the total, respectively) in human kidney cortex. Chiral analysis of the human renal expoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively. These results demonstrate the biosynthetic origin of the human kidney 11,12- and 14,15-epoxyeicosatrienoic acids and suggest a role for renal cytochrome P-450 in the bioactivation of endogenous pools of arachidonic acid.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalFEBS Letters
Volume268
Issue number1
DOIs
StatePublished - Jul 30 1990

Keywords

  • Arachidonic acid
  • Cytochrome P-450
  • Epoxyeicosatrienoic acid
  • Epoxygenase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex'. Together they form a unique fingerprint.

Cite this