Are astrocytes central players in the pathophysiology of multiple sclerosis?

Jacques De Keyser, Esther Zeinstra, Elliot Frohman

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

An interaction between antimyelin T cells and antigen-presenting glial cells is a crucial step in the cascade of immune events that lead to the inflammatory lesions in multiple sclerosis (MS). One of the most debated and controversial issues is whether microglial cells or astrocytes are the key players in initiating the (auto)immune reactions in the central nervous system in MS. Many investigators consider microglia to be the responsible intrinsic immunoeffector cells. In this review, we speculate that in MS astrocytes may serve as primary (facultative) antigen-presenting cells due to a failure of noradrenergic suppression of class II major histocompatibility complex molecules, which is caused by a loss of β2-adrenergic receptors. If this hypothesis is correct, pharmacologic suppression of the antigen-presenting capacities of astrocytes may be a potential therapy for MS.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalArchives of Neurology
Volume60
Issue number1
StatePublished - Jan 1 2003

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Astrocytes
Multiple Sclerosis
Antigen-Presenting Cells
Viral Tumor Antigens
Microglia
Major Histocompatibility Complex
Neuroglia
Adrenergic Receptors
Central Nervous System
Research Personnel
T-Lymphocytes
Antigens
Cells
Therapeutics
Suppression

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Are astrocytes central players in the pathophysiology of multiple sclerosis? / De Keyser, Jacques; Zeinstra, Esther; Frohman, Elliot.

In: Archives of Neurology, Vol. 60, No. 1, 01.01.2003, p. 132-136.

Research output: Contribution to journalArticle

De Keyser, Jacques ; Zeinstra, Esther ; Frohman, Elliot. / Are astrocytes central players in the pathophysiology of multiple sclerosis?. In: Archives of Neurology. 2003 ; Vol. 60, No. 1. pp. 132-136.
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