Are dermal adipocytes involved in psoriasis?

Ilja L. Kruglikov, Philipp E. Scherer, Uwe Wollina

Research output: Contribution to journalLetter

15 Scopus citations

Abstract

There is rapidly growing evidence that adipose tissue is involved in the pathophysiology of psoriasis. Recent results demonstrate that murine skin can react to pathogens with the expansion of its dermal adipose depot and an increased production of antimicrobial peptides, which in turn can cause exacerbation of psoriasis-associated inflammation. We hypothesize that dermal adipocytes rather than subcutaneous adipose tissues are involved in the pathophysiology of psoriasis. This model is supported by the observations that the use of a number of different therapeutic options to alleviate psoriasis invariably leads to a modulation of the dermal adipose tissue. We propose to test this hypothesis through a detailed profiling effort of adipocytes from psoriatic lesions prior to and after psoriasis-relevant therapies.

Original languageEnglish (US)
Pages (from-to)812-813
Number of pages2
JournalExperimental Dermatology
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2016

    Fingerprint

Keywords

  • cathelicidin
  • dermal adipocytes
  • pathophysiology
  • psoriasis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this