Are immunoglobulins integral membrane proteins?

Ulrich Melcher; Leon Eidels; Jonathan W. Uhr

doi:10.1038/258434a0

Are immunoglobulins integral membrane proteins?

Ulrich Melcher, Leon Eidels, Jonathan W. Uhr

Immunology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

IMMUNOGLOBULINS (Igs) are present on the surface of murine bone-marrow derived (B) lymphocytes^1-3. Combination of the membrane Ig and a specific antigen, together with the arrival of a signal from thymus-derived (T) lymphocytes induces B cells to divide and differentiate into antibody secreting plasma cells⁴. To understand the mechanism of that induction, it is necessary to know how Ig is attached to the cell surface.

Original language	English (US)
Pages (from-to)	434-435
Number of pages	2
Journal	Nature
Volume	258
Issue number	5534
DOIs	https://doi.org/10.1038/258434a0
State	Published - 1975

ASJC Scopus subject areas

General

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10.1038/258434a0

Cite this

@article{fc90fc35db444bfb9754671b38009ba6,

title = "Are immunoglobulins integral membrane proteins?",

abstract = "IMMUNOGLOBULINS (Igs) are present on the surface of murine bone-marrow derived (B) lymphocytes1-3. Combination of the membrane Ig and a specific antigen, together with the arrival of a signal from thymus-derived (T) lymphocytes induces B cells to divide and differentiate into antibody secreting plasma cells4. To understand the mechanism of that induction, it is necessary to know how Ig is attached to the cell surface.",

author = "Ulrich Melcher and Leon Eidels and Uhr, {Jonathan W.}",

year = "1975",

doi = "10.1038/258434a0",

language = "English (US)",

volume = "258",

pages = "434--435",

journal = "Nature",

issn = "0028-0836",