Are immunoglobulins integral membrane proteins?

Ulrich Melcher, Leon Eidels, Jonathan W. Uhr

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

IMMUNOGLOBULINS (Igs) are present on the surface of murine bone-marrow derived (B) lymphocytes1-3. Combination of the membrane Ig and a specific antigen, together with the arrival of a signal from thymus-derived (T) lymphocytes induces B cells to divide and differentiate into antibody secreting plasma cells4. To understand the mechanism of that induction, it is necessary to know how Ig is attached to the cell surface.

Original languageEnglish (US)
Pages (from-to)434-435
Number of pages2
JournalNature
Volume258
Issue number5534
DOIs
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • General

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    Melcher, U., Eidels, L., & Uhr, J. W. (1975). Are immunoglobulins integral membrane proteins? Nature, 258(5534), 434-435. https://doi.org/10.1038/258434a0