Are the non-classical auditory pathways involved in autism and PDD?

Aage R. Møller, Janet K. Kern, Bruce Grannemann

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objective: To test the hypothesis that some of the abnormal sensory perceptions that characterize autism may be explained by an abnormal activation of non-classical (extralemniscal) sensory pathways. Methods: Twenty-one individuals, 18-45 years of age who were diagnosed with autism participated in the study. Sounds (clicks presented at a rate of 40 per second and 65 dB above the normal threshold) were applied through earphones. Electrical stimulation (100 μS rectangular impulses at a rate of 4 per second) was applied through electrodes placed on the skin over the median nerve at the wrist. The participants were asked to match the loudness of the sound with and without the electrical stimulation applied to the median nerve. Results: Electrical stimulation of the median nerve at the wrist in individuals with autism could change the perception of loudness of sounds presented to one ear through an earphone showing a statistically significant abnormal sensory cross-modal interaction. Discussion: We interpreted our results to support the hypothesis that some individuals with autism have an abnormal cross-modal interaction between the auditory and the somatosensory systems. Cross-modal interaction between senses such as hearing and we somatosensory system does not occur normally in adults. As only the non-classical (extralemniscal) ascending auditory pathways receive somatosensory input, the presence of cross-modal interaction in autistic individuals is a sign that autism is associated with abnormal involvement of the non-classical auditory pathways, implying that sensory information is processed by different populations of neurons than in non-autistic individuals.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalNeurological Research
Volume27
Issue number6
DOIs
StatePublished - Sep 1 2005

Keywords

  • Auditory pathways
  • Austism
  • PDD

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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