Arginine stimulated hyperglucagonemia in diabetic Pima Indians

S. L. Aronoff, P. H. Bennett, N. B. Rushforth, M. Miller, Roger H Unger

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Groups of 27 nondiabetic Pima Indians, 34 nondiabetic Caucasians, and 12 diabetic Pima Indians with recent onset of their disease received an arginine infusion to determine if (1) nondiabetic Pima Indians and Caucasians had a similar glucagon response to arginine and (2) diabetic Pimas had excessive glucagon response to arginine as reported in other racial groups. The fasting glucagon levels in the three groups were not significantly different. During arginine monochloride infusion (5 mg./kg./minute for 40 minutes) the diabetic Pimas had glucagon levels significantly higher at 10 minutes and at all sampling points thereafter than the normoglycemic Pimas. Plasma insulin levels also increased during the infusion but, notably, never differed significantly between these two groups. There was no significant difference in the glucagon levels at any sampling point between the nondiabetic Pimas and Caucasians. The differences in glucagon levels between the nondiabetic and diabetic Indians are similar to those differences reported between diabetic and nondiabetic subjects of other racial origins.

Original languageEnglish (US)
Pages (from-to)404-407
Number of pages4
JournalDiabetes
Volume25
Issue number5
StatePublished - 1976

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Potassium Iodide
Glucagon
Arginine
Fasting
Insulin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Aronoff, S. L., Bennett, P. H., Rushforth, N. B., Miller, M., & Unger, R. H. (1976). Arginine stimulated hyperglucagonemia in diabetic Pima Indians. Diabetes, 25(5), 404-407.

Arginine stimulated hyperglucagonemia in diabetic Pima Indians. / Aronoff, S. L.; Bennett, P. H.; Rushforth, N. B.; Miller, M.; Unger, Roger H.

In: Diabetes, Vol. 25, No. 5, 1976, p. 404-407.

Research output: Contribution to journalArticle

Aronoff, SL, Bennett, PH, Rushforth, NB, Miller, M & Unger, RH 1976, 'Arginine stimulated hyperglucagonemia in diabetic Pima Indians', Diabetes, vol. 25, no. 5, pp. 404-407.
Aronoff SL, Bennett PH, Rushforth NB, Miller M, Unger RH. Arginine stimulated hyperglucagonemia in diabetic Pima Indians. Diabetes. 1976;25(5):404-407.
Aronoff, S. L. ; Bennett, P. H. ; Rushforth, N. B. ; Miller, M. ; Unger, Roger H. / Arginine stimulated hyperglucagonemia in diabetic Pima Indians. In: Diabetes. 1976 ; Vol. 25, No. 5. pp. 404-407.
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