Arterial stiffness during whole-body passive heat stress in healthy older adults

Zachary J. Schlader, Yoshiyuki Okada, Stuart A. Best, Qi Fu, Craig G Crandall

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that whole-body passive heat stress reduces arterial stiffness in older adults. At preheat stress (baseline) and when core temperature was elevated by 0.6 ± 0.2°C (mild) and 1.2 ± 0.3°C (moderate), arterial stiffness was measured in eight healthy younger (26 ± 5 years) and eight healthy older (70 ± 4 years) adults in the supine position. Arterial stiffness was estimated from carotid-to-femoral pulse wave velocity (cfPWV, applanation tonometry). cfPWV was higher at baseline in older adults (8.8 ± 2.3 m/sec vs. 5.6 ± 0.9 m/sec, P < 0.01) and this difference was maintained throughout passive heat stress (P < 0.01). cfPWV did not change (P ≥ 0.49) with passive heat stress in either younger (at moderate heat stress: 6.0 ± 1.0 m/sec) or older (at moderate heat stress: 8.5 ± 1.6 m/sec) adults. However, the influence of baseline cfPWV on the change in cfPWV during mild (r = −0.66, P = 0.04) and moderate (r = −0.87, P < 0.01) heat stress were inversely related in older adults, and the strength of these relations was not statistically different (P = 0.08). In younger adults, the influence of baseline cfPWV on the change in cfPWV during mild heat stress was also inversely related (r = −0.79, P = 0.01), while the strength of this relation was attenuated at moderate heat stress (r = −0.24, P = 0.30). Changes in arterial stiffness during passive heat stress in adults aged ≥65 year are likely dependent on the magnitude of baseline arterial stiffness and not necessarily age.

Original languageEnglish (US)
Article numbere14094
JournalPhysiological Reports
Volume7
Issue number9
DOIs
StatePublished - May 1 2019

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Vascular Stiffness
Hot Temperature
Pulse Wave Analysis
Supine Position
Manometry
Thigh
Young Adult
Temperature

Keywords

  • Aging
  • arterial compliance
  • central blood pressure
  • hyperthermia
  • pulse wave velocity
  • wave reflection

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Arterial stiffness during whole-body passive heat stress in healthy older adults. / Schlader, Zachary J.; Okada, Yoshiyuki; Best, Stuart A.; Fu, Qi; Crandall, Craig G.

In: Physiological Reports, Vol. 7, No. 9, e14094, 01.05.2019.

Research output: Contribution to journalArticle

Schlader, Zachary J. ; Okada, Yoshiyuki ; Best, Stuart A. ; Fu, Qi ; Crandall, Craig G. / Arterial stiffness during whole-body passive heat stress in healthy older adults. In: Physiological Reports. 2019 ; Vol. 7, No. 9.
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