Arthritis in HLA-B27 transgenic animals

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Abstract

This review focuses on investigations of rats and mice transgenic for HLA-B27; these animals have been investigated for several years as potential models for the human spondyloarthropathies. Spontaneous multisystem disease occurs in rats with high expression of B27 and human β2-microglobulin (hβ2m). The disease is T-cell-dependent and is sensitive to both environmental and genetic manipulation. A spontaneous arthritis and enthesopathy has been observed by some investigators in nontransgenic mice which seems to be more prevalent in B27 transgenic mice. Peripheral arthritis has also been reported in B27 transgenic mice that lack mouse β2m. Potential insights from these animals into the pathogenesis of B27-related disease are discussed.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalAmerican Journal of the Medical Sciences
Volume316
Issue number4
DOIs
StatePublished - Oct 1998

Keywords

  • Arthritis
  • HLA-B27
  • Human β- microglobulin
  • Spondyloarthropathies
  • Transgenic animals

ASJC Scopus subject areas

  • Medicine(all)

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