Ascending Aortic Dimensions in Former National Football League Athletes

James L. Gentry, David Carruthers, Parag Joshi, Christopher D. Maroules, Colby R. Ayers, James A de Lemos, Philip Aagaard, Rory Hachamovitch, Milind Y. Desai, Eric E. Roselli, Reginald E. Dunn, Kezia Alexander, Andrew E. Lincoln, Andrew M. Tucker, Dermot M. Phelan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND: Ascending aortic dimensions are slightly larger in young competitive athletes compared with sedentary controls, but rarely >40 mm. Whether this finding translates to aortic enlargement in older, former athletes is unknown.

METHODS AND RESULTS: This cross-sectional study involved a sample of 206 former National Football League (NFL) athletes compared with 759 male subjects from the DHS-2 (Dallas Heart Study-2; mean age of 57.1 and 53.6 years, respectively, P<0.0001; body surface area of 2.4 and 2.1 m2, respectively, P<0.0001). Midascending aortic dimensions were obtained from computed tomographic scans performed as part of a NFL screening protocol or as part of the DHS. Compared with a population-based control group, former NFL athletes had significantly larger ascending aortic diameters (38±5 versus 34±4 mm; P<0.0001). A significantly higher proportion of former NFL athletes had an aorta of >40 mm (29.6% versus 8.6%; P<0.0001). After adjusting for age, race, body surface area, systolic blood pressure, history of hypertension, current smoking, diabetes mellitus, and lipid profile, the former NFL athletes still had significantly larger ascending aortas (P<0.0001). Former NFL athletes were twice as likely to have an aorta >40 mm after adjusting for the same parameters.

CONCLUSIONS: Ascending aortic dimensions were significantly larger in a sample of former NFL athletes after adjusting for their size, age, race, and cardiac risk factors. Whether this translates to an increased risk is unknown and requires further evaluation.

Original languageEnglish (US)
JournalCirculation. Cardiovascular imaging
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Football
Athletes
Cross-Sectional Studies
adjuvant P40

Keywords

  • aorta
  • athletes
  • body surface area
  • football
  • hypertension

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Ascending Aortic Dimensions in Former National Football League Athletes. / Gentry, James L.; Carruthers, David; Joshi, Parag; Maroules, Christopher D.; Ayers, Colby R.; de Lemos, James A; Aagaard, Philip; Hachamovitch, Rory; Desai, Milind Y.; Roselli, Eric E.; Dunn, Reginald E.; Alexander, Kezia; Lincoln, Andrew E.; Tucker, Andrew M.; Phelan, Dermot M.

In: Circulation. Cardiovascular imaging, Vol. 10, No. 11, 01.11.2017.

Research output: Contribution to journalArticle

Gentry, JL, Carruthers, D, Joshi, P, Maroules, CD, Ayers, CR, de Lemos, JA, Aagaard, P, Hachamovitch, R, Desai, MY, Roselli, EE, Dunn, RE, Alexander, K, Lincoln, AE, Tucker, AM & Phelan, DM 2017, 'Ascending Aortic Dimensions in Former National Football League Athletes', Circulation. Cardiovascular imaging, vol. 10, no. 11. https://doi.org/10.1161/CIRCIMAGING.117.006852
Gentry, James L. ; Carruthers, David ; Joshi, Parag ; Maroules, Christopher D. ; Ayers, Colby R. ; de Lemos, James A ; Aagaard, Philip ; Hachamovitch, Rory ; Desai, Milind Y. ; Roselli, Eric E. ; Dunn, Reginald E. ; Alexander, Kezia ; Lincoln, Andrew E. ; Tucker, Andrew M. ; Phelan, Dermot M. / Ascending Aortic Dimensions in Former National Football League Athletes. In: Circulation. Cardiovascular imaging. 2017 ; Vol. 10, No. 11.
@article{064e8562e86f483d9000d0c24498192e,
title = "Ascending Aortic Dimensions in Former National Football League Athletes",
abstract = "BACKGROUND: Ascending aortic dimensions are slightly larger in young competitive athletes compared with sedentary controls, but rarely >40 mm. Whether this finding translates to aortic enlargement in older, former athletes is unknown.METHODS AND RESULTS: This cross-sectional study involved a sample of 206 former National Football League (NFL) athletes compared with 759 male subjects from the DHS-2 (Dallas Heart Study-2; mean age of 57.1 and 53.6 years, respectively, P<0.0001; body surface area of 2.4 and 2.1 m2, respectively, P<0.0001). Midascending aortic dimensions were obtained from computed tomographic scans performed as part of a NFL screening protocol or as part of the DHS. Compared with a population-based control group, former NFL athletes had significantly larger ascending aortic diameters (38±5 versus 34±4 mm; P<0.0001). A significantly higher proportion of former NFL athletes had an aorta of >40 mm (29.6{\%} versus 8.6{\%}; P<0.0001). After adjusting for age, race, body surface area, systolic blood pressure, history of hypertension, current smoking, diabetes mellitus, and lipid profile, the former NFL athletes still had significantly larger ascending aortas (P<0.0001). Former NFL athletes were twice as likely to have an aorta >40 mm after adjusting for the same parameters.CONCLUSIONS: Ascending aortic dimensions were significantly larger in a sample of former NFL athletes after adjusting for their size, age, race, and cardiac risk factors. Whether this translates to an increased risk is unknown and requires further evaluation.",
keywords = "aorta, athletes, body surface area, football, hypertension",
author = "Gentry, {James L.} and David Carruthers and Parag Joshi and Maroules, {Christopher D.} and Ayers, {Colby R.} and {de Lemos}, {James A} and Philip Aagaard and Rory Hachamovitch and Desai, {Milind Y.} and Roselli, {Eric E.} and Dunn, {Reginald E.} and Kezia Alexander and Lincoln, {Andrew E.} and Tucker, {Andrew M.} and Phelan, {Dermot M.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1161/CIRCIMAGING.117.006852",
language = "English (US)",
volume = "10",
journal = "Circulation. Cardiovascular imaging",
issn = "1941-9651",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Ascending Aortic Dimensions in Former National Football League Athletes

AU - Gentry, James L.

AU - Carruthers, David

AU - Joshi, Parag

AU - Maroules, Christopher D.

AU - Ayers, Colby R.

AU - de Lemos, James A

AU - Aagaard, Philip

AU - Hachamovitch, Rory

AU - Desai, Milind Y.

AU - Roselli, Eric E.

AU - Dunn, Reginald E.

AU - Alexander, Kezia

AU - Lincoln, Andrew E.

AU - Tucker, Andrew M.

AU - Phelan, Dermot M.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - BACKGROUND: Ascending aortic dimensions are slightly larger in young competitive athletes compared with sedentary controls, but rarely >40 mm. Whether this finding translates to aortic enlargement in older, former athletes is unknown.METHODS AND RESULTS: This cross-sectional study involved a sample of 206 former National Football League (NFL) athletes compared with 759 male subjects from the DHS-2 (Dallas Heart Study-2; mean age of 57.1 and 53.6 years, respectively, P<0.0001; body surface area of 2.4 and 2.1 m2, respectively, P<0.0001). Midascending aortic dimensions were obtained from computed tomographic scans performed as part of a NFL screening protocol or as part of the DHS. Compared with a population-based control group, former NFL athletes had significantly larger ascending aortic diameters (38±5 versus 34±4 mm; P<0.0001). A significantly higher proportion of former NFL athletes had an aorta of >40 mm (29.6% versus 8.6%; P<0.0001). After adjusting for age, race, body surface area, systolic blood pressure, history of hypertension, current smoking, diabetes mellitus, and lipid profile, the former NFL athletes still had significantly larger ascending aortas (P<0.0001). Former NFL athletes were twice as likely to have an aorta >40 mm after adjusting for the same parameters.CONCLUSIONS: Ascending aortic dimensions were significantly larger in a sample of former NFL athletes after adjusting for their size, age, race, and cardiac risk factors. Whether this translates to an increased risk is unknown and requires further evaluation.

AB - BACKGROUND: Ascending aortic dimensions are slightly larger in young competitive athletes compared with sedentary controls, but rarely >40 mm. Whether this finding translates to aortic enlargement in older, former athletes is unknown.METHODS AND RESULTS: This cross-sectional study involved a sample of 206 former National Football League (NFL) athletes compared with 759 male subjects from the DHS-2 (Dallas Heart Study-2; mean age of 57.1 and 53.6 years, respectively, P<0.0001; body surface area of 2.4 and 2.1 m2, respectively, P<0.0001). Midascending aortic dimensions were obtained from computed tomographic scans performed as part of a NFL screening protocol or as part of the DHS. Compared with a population-based control group, former NFL athletes had significantly larger ascending aortic diameters (38±5 versus 34±4 mm; P<0.0001). A significantly higher proportion of former NFL athletes had an aorta of >40 mm (29.6% versus 8.6%; P<0.0001). After adjusting for age, race, body surface area, systolic blood pressure, history of hypertension, current smoking, diabetes mellitus, and lipid profile, the former NFL athletes still had significantly larger ascending aortas (P<0.0001). Former NFL athletes were twice as likely to have an aorta >40 mm after adjusting for the same parameters.CONCLUSIONS: Ascending aortic dimensions were significantly larger in a sample of former NFL athletes after adjusting for their size, age, race, and cardiac risk factors. Whether this translates to an increased risk is unknown and requires further evaluation.

KW - aorta

KW - athletes

KW - body surface area

KW - football

KW - hypertension

UR - http://www.scopus.com/inward/record.url?scp=85038221511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038221511&partnerID=8YFLogxK

U2 - 10.1161/CIRCIMAGING.117.006852

DO - 10.1161/CIRCIMAGING.117.006852

M3 - Article

VL - 10

JO - Circulation. Cardiovascular imaging

JF - Circulation. Cardiovascular imaging

SN - 1941-9651

IS - 11

ER -