Ascent to altitude as a weight loss method

The good and bad of hypoxia inducible factor activation

Biff F. Palmer, Deborah J. Clegg

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective Given the epidemic of obesity worldwide there is a need for more novel and effective weight loss methods. Altitude is well known to be associated with weight loss and has actually been used as a method of weight reduction in obese subjects. This review demonstrates the critical role of hypoxia inducible factor (HIF) in bringing about reductions in appetite and increases in energy expenditure characteristic of hypobaric hypoxia Design and Methods A MEDLINE search of English language articles through February 2013 identified publications associating altitude or hypobaric hypoxia with key words to include HIF, weight loss, appetite, basal metabolic rate, leptin, cellular energetics, and obesity. The data from these articles were synthesized to formulate a unique and novel mechanism by which HIF activation leads to alterations in appetite, basal metabolic rate, and reductions in body adiposity. Results A synthesis of previously published literature revealed mechanisms by which altitude induces activation of HIF, thereby suggesting this transcription factor regulates changes in cellular metabolism/energetics, activation of the central nervous system, as well as peripheral pathways leading to reductions in food intake and increases in energy expenditure. Conclusions Here a unifying hypothesis is present suggesting that activation of HIF under conditions of altitude potentially leads to metabolic benefits that are dose dependent, gender and genetic specific, and results in adverse effects if the exposure is extreme.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalObesity
Volume22
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Weight Loss
Appetite
Basal Metabolism
Energy Metabolism
Obesity
Adiposity
Leptin
Hypoxia
MEDLINE
Publications
Transcription Factors
Language
Central Nervous System
Eating

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Ascent to altitude as a weight loss method : The good and bad of hypoxia inducible factor activation. / Palmer, Biff F.; Clegg, Deborah J.

In: Obesity, Vol. 22, No. 2, 02.2014, p. 311-317.

Research output: Contribution to journalArticle

@article{f524336a0f2a4ee98faf9c6aa402fa5d,
title = "Ascent to altitude as a weight loss method: The good and bad of hypoxia inducible factor activation",
abstract = "Objective Given the epidemic of obesity worldwide there is a need for more novel and effective weight loss methods. Altitude is well known to be associated with weight loss and has actually been used as a method of weight reduction in obese subjects. This review demonstrates the critical role of hypoxia inducible factor (HIF) in bringing about reductions in appetite and increases in energy expenditure characteristic of hypobaric hypoxia Design and Methods A MEDLINE search of English language articles through February 2013 identified publications associating altitude or hypobaric hypoxia with key words to include HIF, weight loss, appetite, basal metabolic rate, leptin, cellular energetics, and obesity. The data from these articles were synthesized to formulate a unique and novel mechanism by which HIF activation leads to alterations in appetite, basal metabolic rate, and reductions in body adiposity. Results A synthesis of previously published literature revealed mechanisms by which altitude induces activation of HIF, thereby suggesting this transcription factor regulates changes in cellular metabolism/energetics, activation of the central nervous system, as well as peripheral pathways leading to reductions in food intake and increases in energy expenditure. Conclusions Here a unifying hypothesis is present suggesting that activation of HIF under conditions of altitude potentially leads to metabolic benefits that are dose dependent, gender and genetic specific, and results in adverse effects if the exposure is extreme.",
author = "Palmer, {Biff F.} and Clegg, {Deborah J.}",
year = "2014",
month = "2",
doi = "10.1002/oby.20499",
language = "English (US)",
volume = "22",
pages = "311--317",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Ascent to altitude as a weight loss method

T2 - The good and bad of hypoxia inducible factor activation

AU - Palmer, Biff F.

AU - Clegg, Deborah J.

PY - 2014/2

Y1 - 2014/2

N2 - Objective Given the epidemic of obesity worldwide there is a need for more novel and effective weight loss methods. Altitude is well known to be associated with weight loss and has actually been used as a method of weight reduction in obese subjects. This review demonstrates the critical role of hypoxia inducible factor (HIF) in bringing about reductions in appetite and increases in energy expenditure characteristic of hypobaric hypoxia Design and Methods A MEDLINE search of English language articles through February 2013 identified publications associating altitude or hypobaric hypoxia with key words to include HIF, weight loss, appetite, basal metabolic rate, leptin, cellular energetics, and obesity. The data from these articles were synthesized to formulate a unique and novel mechanism by which HIF activation leads to alterations in appetite, basal metabolic rate, and reductions in body adiposity. Results A synthesis of previously published literature revealed mechanisms by which altitude induces activation of HIF, thereby suggesting this transcription factor regulates changes in cellular metabolism/energetics, activation of the central nervous system, as well as peripheral pathways leading to reductions in food intake and increases in energy expenditure. Conclusions Here a unifying hypothesis is present suggesting that activation of HIF under conditions of altitude potentially leads to metabolic benefits that are dose dependent, gender and genetic specific, and results in adverse effects if the exposure is extreme.

AB - Objective Given the epidemic of obesity worldwide there is a need for more novel and effective weight loss methods. Altitude is well known to be associated with weight loss and has actually been used as a method of weight reduction in obese subjects. This review demonstrates the critical role of hypoxia inducible factor (HIF) in bringing about reductions in appetite and increases in energy expenditure characteristic of hypobaric hypoxia Design and Methods A MEDLINE search of English language articles through February 2013 identified publications associating altitude or hypobaric hypoxia with key words to include HIF, weight loss, appetite, basal metabolic rate, leptin, cellular energetics, and obesity. The data from these articles were synthesized to formulate a unique and novel mechanism by which HIF activation leads to alterations in appetite, basal metabolic rate, and reductions in body adiposity. Results A synthesis of previously published literature revealed mechanisms by which altitude induces activation of HIF, thereby suggesting this transcription factor regulates changes in cellular metabolism/energetics, activation of the central nervous system, as well as peripheral pathways leading to reductions in food intake and increases in energy expenditure. Conclusions Here a unifying hypothesis is present suggesting that activation of HIF under conditions of altitude potentially leads to metabolic benefits that are dose dependent, gender and genetic specific, and results in adverse effects if the exposure is extreme.

UR - http://www.scopus.com/inward/record.url?scp=84895910139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895910139&partnerID=8YFLogxK

U2 - 10.1002/oby.20499

DO - 10.1002/oby.20499

M3 - Article

VL - 22

SP - 311

EP - 317

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 2

ER -